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SenesTech, Inc. () is an
ContraPest is a sugary liquid, designed to be attractive to, and to be consumed by rats in order to eliminate future potential offspring. However, it does not sterilize the rats, so a continuous supply is required. The company claims that in field tests, ContraPest use caused a reduction in rat populations of roughly 40% over a period of 12 weeks or longer.
The product was approved for commercial use by the U.S. Environmental Protection Agency in August 2016. Removal of the "Restricted Use Only" label from ContraPest was permitted by the EPA in October 2018. The active ingredients of ContraPest are
agricultural
Agriculture or farming is the practice of cultivating plants and livestock. Agriculture was the key development in the rise of sedentary human civilization, whereby farming of domesticated species created food surpluses that enabled peopl ...
biotechnology
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used b ...
life-sciences company, specializing in fertility management as a form of pest control
Pest control is the regulation or management of a species defined as a pest; any animal, plant or fungus that impacts adversely on human activities or environment. The human response depends on the importance of the damage done and will range ...
. The company's primary product, ContraPest
ContraPest is the first U.S. EPA registered contraceptive pest control tool designed to reduce fertility in brown and black rats, developed by the U.S. biotechnology company SenesTech. It is a flavored liquid, designed to be attractive to, and ...
is designed to make brown
Brown is a color. It can be considered a composite color, but it is mainly a darker shade of orange. In the CMYK color model used in printing or painting, brown is usually made by combining the colors orange and black. In the RGB color model use ...
and black rats
The black rat (''Rattus rattus''), also known as the roof rat, ship rat, or house rat, is a common long-tailed rodent of the stereotypical rat genus ''Rattus'', in the subfamily Murinae. It likely originated in the Indian subcontinent, but is n ...
infertile. SenesTech is headquartered in Phoenix, Arizona
Phoenix ( ; nv, Hoozdo; es, Fénix or , yuf-x-wal, Banyà:nyuwá) is the capital and most populous city of the U.S. state of Arizona, with 1,608,139 residents as of 2020. It is the fifth-most populous city in the United States, and the o ...
.
History
The company was founded by Dr. Loretta Mayer and several colleagues, who were researching menopause in rodents. The commercial applications of their research became apparent, and they incorporated SenesTech in 2004. In 2019, SenesTech began selling directly to the public.Products
ContraPest
ContraPest is a sugary liquid, designed to be attractive to, and to be consumed by rats in order to eliminate future potential offspring. However, it does not sterilize the rats, so a continuous supply is required. The company claims that in field tests, ContraPest use caused a reduction in rat populations of roughly 40% over a period of 12 weeks or longer.
The product was approved for commercial use by the U.S. Environmental Protection Agency in August 2016. Removal of the "Restricted Use Only" label from ContraPest was permitted by the EPA in October 2018. The active ingredients of ContraPest are 4-vinylcyclohexene diepoxide
4-Vinylcyclohexene dioxide (VCD) is an organic compound that contains two epoxide functional groups. It is industrially used as a crosslinking agent for the production of epoxy resins. It is a colourless liquid. It is an intermediate for synthes ...
(VCD), which reduces oocyte
An oocyte (, ), oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction. In other words, it is an immature ovum, or egg cell. An oocyte is produced in a female fetus in the ovary during female gametogenesis. The femal ...
s in immature ovarian follicle
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle. At the time of puberty, women have approximately 200,000 to 300,000 follicles, each with t ...
s and triptolide
Triptolide is a diterpenoid epoxide which is produced by the thunder god vine, ''Tripterygium wilfordii''. It has ''in vitro'' and ''in vivo'' activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical p ...
reducing reproductive effects on both males and females.
In November 2023, Senestech released a new soft bait product with a different active ingredient, called Evolve. It is also a fertility control product.{{Citation needed, date=November 2023
See also
*4-vinylcyclohexene diepoxide
4-Vinylcyclohexene dioxide (VCD) is an organic compound that contains two epoxide functional groups. It is industrially used as a crosslinking agent for the production of epoxy resins. It is a colourless liquid. It is an intermediate for synthes ...
* Pest control
Pest control is the regulation or management of a species defined as a pest; any animal, plant or fungus that impacts adversely on human activities or environment. The human response depends on the importance of the damage done and will range ...
References