Samuel L. may refer to:
*
Samuel L. Jackson (born 1948), American actor
* Samuel L. Clemens aka
Mark Twain (1835 – 1910), American author
*
Samuel L. Devine (1915 – 1997), American politician
*
Samuel L. Gravely Jr. (1922 – 2004) African-American naval officer
*
Samuel L. Greitzer (1905 – 1988), American mathematician
*
Samuel L. Lewis (1896 – 1971) American mystic and horticulturalist
*
Samuel L. Mitchill (1764–1831) American physician, naturalist, and politician
*
Samuel L. Popkin (born 1942), American political scientist
*
Samuel L. Southard (1787 – 1842), American statesman
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