SISD

SISD can refer to:

* Single instruction, single data, a computer processor architecture
* CCL5, an 8kDa protein also using the symbol SISD
* Sixteen-segment display
* Several school districts in Texas. See List of school districts in Texas - S
* Saginaw Intermediate School District (Michigan)
* Southeast Island School District (Alaska)
* Swiss International Scientific School in Dubai
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