SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85, in rodents - Ruk) is an adaptor protein that in humans is encoded by the ''SH3KBP1''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon

tyrosine phosphorylation Tyrosine phosphorylation is the addition of a phosphate () group to the amino acid tyrosine on a protein. It is one of the main types of protein phosphorylation. This transfer is made possible through enzymes called tyrosine kinases. Tyrosine phos ...

, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances

tumor necrosis factor Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors o ...

(MIM 191160)-mediated apoptotic cell death (Narita et al., 2001). upplied by OMIMref name="entrez">

Interactions

SH3KBP1 has been shown to interact with

B-cell linker B-cell linker (BLNK) protein is expressed in B cells and macrophages and plays a large role in B cell receptor signaling. Like all adaptor proteins, BLNK has no known intrinsic enzymatic activity. Its function is to temporally and spatially coo ...

Grb2 Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/ cell communication. In humans, the GRB2 protein is encoded by the ''GRB2'' gene. The protein encoded by this gene binds recepto ...

, SH3GLB2, SH3GL3,

SH3GL2 Endophilin-A1 is a protein that in humans is encoded by the ''SH3GL2'' gene. Interactions SH3GL2 has been shown to interact with DNM1, Amphiphysin, ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in huma ...

, BCAR1,

Epidermal growth factor receptor The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor (biochemistry), receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligand (biochemistry ...

, CBLB,

Cbl gene E3 ubiquitin-protein ligase CBL is an enzyme that is humans is encoded by the ''CBL'' (Casitas B-lineage Lymphoma) gene. ''CBL'' gene is the founding member the Cbl family. The protein CBL which is an Ubiquitin ligase, E3 ubiquitin-protein liga ...

SOS1 Son of sevenless homolog 1 is a protein that in humans is encoded by the ''SOS1'' gene. Function SOS1 is a guanine nucleotide exchange factor (GEF) which interacts with Ras protein, Ras proteins to phosphorylate GDP into GTP, or from an inacti ...

, CRK and PAK2.

Function

Interactions

References

Further reading