Robert C. Green
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Robert C. Green is an American medical geneticist, physician, and public health researcher. He directs the Genomes2People Research Program in translational genomics and health outcomes in the Division of Genetics at
Brigham and Women's Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts Gener ...
and the
Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, Cambridge, Massachusetts, U ...
, and is Director of the Preventive Genomics Clinic at
Brigham and Women's Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts Gener ...
. Research led by Green includes clinical and research aspects of genomic and precision medicine, including the development and disclosure of Alzheimer's disease risk estimates (the REVEAL Study) and one of the first prospective studies of direct-to-consumer genetic testing services (the PGen Study). He has studied the implementation of medical sequencing in healthy adults (the MedSeq Project), newborns (the BabySeq Project), and active duty military personnel (the MilSeq Project). As of 2020, he is leading the first research collaboration to explore return of genomic results and better understand penetrance in a population-based cohort of underrepresented minorities. He has led the Preventive Genomics Clinic at
Brigham and Women's Hospital Brigham and Women's Hospital (BWH) is the second largest teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts Gener ...
since its creation in 2019.


Education

Green was born in Richmond, Virginia, and attended
Amherst College Amherst College ( ) is a private liberal arts college in Amherst, Massachusetts. Founded in 1821 as an attempt to relocate Williams College by its then-president Zephaniah Swift Moore, Amherst is the third oldest institution of higher educatio ...
and the
University of Virginia School of Medicine The University of Virginia School of Medicine (UVA SoM) is the graduate medical school of the University of Virginia. The school's facilities are on the University of Virginia grounds adjacent to Academical Village in Charlottesville, Virginia. ...
, and earned a Masters of Public Health in Epidemiology from
Emory University Emory University is a private research university in Atlanta, Georgia. Founded in 1836 as "Emory College" by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory, Emory is the second-oldest private institution of ...
School of Public Health. He completed a residency in neurology at Harvard Medical School's Longwood Neurology Program, and research fellowships at
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) in Boston, Massachusetts is a teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital (founded in 1916) and New England Deaconess Hospital (founded ...
and Boston Children's Hospital. Green is board-certified in neurology and medical genetics. He was previously on the faculty at Emory University School of Medicine and the Boston University School of Medicine.


Genomic Research Projects and Contributions

Green served as Principal Investigator of the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study, which explored the behavioral, and health-related impact of disclosing genetic risk for Alzheimer's disease. The study was a series of multi-site, randomized, controlled clinical trials that provide empirical data to address ethical, social and translational issues in genetic susceptibility testing for common diseases. Green also co-led (with J. Scott Roberts, Ph.D.) the Impact of Personal Genomics (PGen) Study, one of the first to investigate the characteristics of consumers; the behavioral and health impact; and the translational and social issues associated with personal genomic testing services. He co-led the incidental findings working group for the
American College of Medical Genetics and Genomics The American College of Medical Genetics and Genomics (ACMG) is an organization composed of biochemical, clinical, cytogenetic, medical and molecular geneticists, genetic counselors and other health care professionals committed to the practice of ...
and was lead author on the controversial recommendations for reporting incidental and secondary findings in clinical exome and genome sequencing. Green also contributed to the design of a variant classification pipeline, and a single page summary for reporting clinically relevant results of whole genome sequencing to physicians. Green currently leads and co-leads the first NIH funded randomized trials of sequencing in adults (MedSeq Project), newborns (BabySeq Project), and active duty US military personnel (MilSeq Project). With continuous funding from NIH for 26 years, he has published more than 300 papers with an h index of 90. Green co-chaired the steering committee of both the Clinical Sequencing Exploratory Research program (18 NIH grants, over 300 investigators), and the steering committee of the Newborn Sequencing in Genomic Medicine and Public Health program (4 NIH grants, over 100 investigators). He is a currently a co-investigator on the Boston site within the
Electronic Medical Records and Genomics Network The Electronic Medical Records and Genomics Network (abbreviated the eMERGE Network) is a consortium of American medical institutions dedicated to advancing the use of electronic medical records for genomics research. It was established in 2007 and ...
(eMERGE). He is Associate Director for Research of Partners HealthCare Personalized Medicine, and is leading the development of protocols for return of genomic results for the
All of Us (initiative) The All of Us Research Program (previously known as the Precision Medicine Initiative Cohort Program) is a research program created in 2015 during the tenure of Barack Obama with $130 million in funding that aims to make advances in tailoring med ...
Research Program of the United States Precision Medicine Initiative and the Google/Verily Project
Baseline Study Project Baseline is a broad effort to map human health led by Verily Life Sciences (formerly Google Life Sciences), Alphabet, Inc.'s health sciences division, and was announced in the Wall Street Journal on July 24, 2014. It begins with the Projec ...
.


Professional Affiliations and Awards

Green directs the Genomes2People Research Program at Brigham Health and is the founding director of the
Brigham Preventive Genomics Clinic Brigham may refer to: Places * Brigham, Cumbria, England * Brigham, East Riding of Yorkshire, England * Brigham City, Utah, USA * Brigham, Wisconsin, USA * Brigham, Quebec, Canada People * Brigham (surname), including a list of people with t ...
. He is Associate Director for Research of Partners HealthCare Personalized Medicine and a member of the executive committee for the Partners BioBank. He is a board member of the
Council for Responsible Genetics The Council for Responsible Genetics (CRG) was a nonprofit NGO with a focus on biotechnology. History The Council for Responsible Genetics was founded in 1983 in Cambridge, Massachusetts. An early voice concerned about the social and ethical ...
. He was previously co-chair of the steering committee of the NIH Consortium in Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT). Green is a member of the Consortium on Electronic Medical Records and Genomics (eMERGE). He served on the Institute of Medicine Committee on the "Evidence Base for Genetic Testing," and has collaborated on research studies with Illumina (company), 23andMe, Pathway and Google. Green received the 2014 Coriell Award for Scientific Achievement in Personalized Medicine. BIS Research named Green one of the 25 most influential voices in precision medicine in 2019.


References

{{DEFAULTSORT:Green, Robert C. Living people American geneticists Harvard Medical School faculty Amherst College alumni University of Virginia School of Medicine alumni 1954 births Rollins School of Public Health alumni