Ronald Keith Siegel (January 2, 1943 – March 24, 2019) was an American psychopharmacologist who was an associate research professor in the Department of Psychiatry and Biobehavioral Sciences at the

University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public university, public Land-grant university, land-grant research university in Los Angeles, California, United States. Its academic roots were established in 1881 as a normal school the ...

. Siegel was the author of several noted studies and books on

psychopharmacology Psychopharmacology (from Greek ; ; and ) is the scientific study of the effects drugs have on mood, sensation, thinking, behavior, judgment and evaluation, and memory. It is distinguished from neuropsychopharmacology, which emphasizes ...

hallucination A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality. They are distinguishable from several related phenomena, such as dreaming ( REM sleep), which does not involve wakefulness; pse ...

, and

paranoia Paranoia is an instinct or thought process that is believed to be heavily influenced by anxiety, suspicion, or fear, often to the point of delusion and irrationality. Paranoid thinking typically includes persecutory beliefs, or beliefs of co ...

. A native of

Herkimer, New York Herkimer is a Administrative divisions of New York#Town, town in Herkimer County, New York, United States, southeast of Utica, New York, Utica. It is named after Nicholas Herkimer. The population was 9,566 at the 2020 census, down from 10,175 in ...

, he received his B.A. in

sociology Sociology is the scientific study of human society that focuses on society, human social behavior, patterns of Interpersonal ties, social relationships, social interaction, and aspects of culture associated with everyday life. The term sociol ...

from

Brandeis University Brandeis University () is a Private university, private research university in Waltham, Massachusetts, United States. It is located within the Greater Boston area. Founded in 1948 as a nonsectarian, non-sectarian, coeducational university, Bra ...

and his Ph.D. in

psychology Psychology is the scientific study of mind and behavior. Its subject matter includes the behavior of humans and nonhumans, both consciousness, conscious and Unconscious mind, unconscious phenomena, and mental processes such as thoughts, feel ...

from

Dalhousie University Dalhousie University (commonly known as Dal) is a large public research university in Nova Scotia, Canada, with three campuses in Halifax, Nova Scotia, Halifax, a fourth in Bible Hill, Nova Scotia, Bible Hill, and a second medical school campus ...

. He was affiliated with the

Albert Einstein College of Medicine The Albert Einstein College of Medicine is a Private university, private medical school in New York City. Founded in 1953, Einstein is an independent degree-granting institution within the Montefiore Einstein Health System. Einstein hosts Doc ...

Yeshiva University Yeshiva University is a Private university, private Modern Orthodox Judaism, Orthodox Jewish university with four campuses in New York City.

before joining the research faculty of UCLA in 1972, where he remained until his retirement in 2008. Throughout his career, he was a consultant to several government commissions on drug use. His research focused on the effects of drugs on human behavior, including numerous clinical studies in which human volunteers (sometimes referred to by Siegel as "

psychonaut Psychonautics (from the Ancient Greek ' 'soul, spirit, mind' and ' 'sailor, navigator') refers both to a methodology for describing and explaining the subjective effects of altered states of consciousness, including those induced by meditati ...

s") took drugs such as

ketamine Ketamine is a cyclohexanone-derived general anesthetic and NMDA receptor antagonist with analgesic and hallucinogenic properties, used medically for anesthesia, depression, and pain management. Ketamine exists as its S- (esketamine) a ...

LSD Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...

marijuana Cannabis (), commonly known as marijuana (), weed, pot, and ganja, List of slang names for cannabis, among other names, is a non-chemically uniform psychoactive drug from the ''Cannabis'' plant. Native to Central or South Asia, cannabis has ...

mescaline Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...

psilocybin Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...

, and THC. In 2005, Siegel was an expert witness for the defense in the Robert Blake murder trial, testifying on the long-term effects of

methamphetamine Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug use, recreational or Performance-enhancing substance, performance-enhancing drug and less commonly as a secon ...

and

cocaine Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...

use. According to the jury foreman in the trial, Siegel was "one of the most compelling witnesses" in discrediting the testimony of Ronald Hambleton, who claimed that Blake had asked him to murder Bonnie Lee Bakley. In the course of his testimony in the Blake trial, Siegel disclosed that in one study, he had taught monkeys to smoke

crack cocaine Crack cocaine, commonly known simply as crack, and also known as rock, is a free base form of the stimulant cocaine that can be Smoking, smoked. Crack offers a short, intense Euphoria (emotion), high to smokers. The ''Manual of Adolescent Sub ...

. He died on March 24, 2019, from complications of

Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...

Bibliography

* (with Jolly West) *''Intoxication: The Universal Drive for Mind-Altering Substances'' (1989, 2005) * *'' Whispers: The Voices of Paranoia'' (1994) * * *

Notes

{{DEFAULTSORT:Siegel, Ronald K American pharmacologists Psychopharmacologists Psychedelic drug researchers American medical writers American male non-fiction writers Harvard Medical School people David Geffen School of Medicine at UCLA faculty Albert Einstein College of Medicine alumni 1943 births 2019 deaths