Rocaglamide is a natural product which belongs to a class of molecules called
flavaglines. This compound was isolated in 1982 by Ming-Lu King (金明儒) and colleagues based on its antileukemic activity. The name of Rocaglamide is named from two parts: Roc- and aglamide. Roc- means Republic of China (中華民國), where this product was first isolated; aglamide indicates this product is isolated from Large-leaved ''Aglaia'' (Scientific name: ''
Aglaia rimosa''
Rocaglamide was first synthesized by
Barry Trost
Barry M. Trost (born June 13, 1941, in Philadelphia) is an American chemist who is the Job and Gertrud Tamaki Professor Emeritus in the School of Humanities and Sciences at Stanford University. The Tsuji–Trost reaction and the Trost ligand ar ...
in 1990.
Although other syntheses have been described since, Trost’s remains the only one to afford rocaglamide in an
enantio-specific manner.
See also
*
FL3 (flavagline)
*
Eukaryotic translation
Eukaryotic translation is the biological process by which messenger RNA is Translation (biology), translated into proteins in eukaryotes. It consists of four phases: initiation, elongation, termination, and recapping.
Initiation
Translation init ...
*
eIF4A
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of Messenger RNA, mRNA to 40S ribosome, ribosomal subunits. In addition these prot ...
*
Silvestrol
References
Carboxamides
{{organic-compound-stub