Retinitis is
inflammation
Inflammation (from ) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin ''calor'', '' ...
of the
retina
The retina (; or retinas) is the innermost, photosensitivity, light-sensitive layer of tissue (biology), tissue of the eye of most vertebrates and some Mollusca, molluscs. The optics of the eye create a focus (optics), focused two-dimensional ...
in the
eye
An eye is a sensory organ that allows an organism to perceive visual information. It detects light and converts it into electro-chemical impulses in neurons (neurones). It is part of an organism's visual system.
In higher organisms, the ey ...
, which can permanently damage the retina and lead to blindness. The retina is the eye's "sensing" tissue. Retinitis may be caused by a number of different infectious agents. Its most common form, called retinitis pigmentosa, has a prevalence of one in every 2,500–7,000 people. This condition is one of the leading causes that leads to blindness in patients in the age range of 20–60 years old.
Retinitis may be caused by several infectious agents, including
toxoplasmosis
Toxoplasmosis is a parasitic disease caused by ''Toxoplasma gondii'', an apicomplexan. Infections with toxoplasmosis are associated with a variety of neuropsychiatric and behavioral conditions. Occasionally, people may have a few weeks or month ...
,
cytomegalovirus
''Cytomegalovirus'' (CMV) (from ''cyto-'' 'cell' via Greek - 'container' + 'big, megalo-' + -''virus'' via Latin 'poison') is a genus of viruses in the order '' Herpesvirales'', in the family '' Herpesviridae'', in the subfamily '' Betaherp ...
and
candida
Candida, or Cándida (Spanish), may refer to:
Biology and medicine
* ''Candida'' (fungus), a genus of yeasts
** Candidiasis, an infection by ''Candida'' organisms
* Malvasia Candida, a variety of grape
Places
* Candida, Campania, a ''comu ...
.
Cytomegalovirus retinitis is an important cause of blindness in
AIDS
The HIV, human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system. Without treatment, it can lead to a spectrum of conditions including acquired immunodeficiency syndrome (AIDS). It is a Preventive healthcare, pr ...
patients.
Candida spreading to the retina from the bloodstream usually results in the production of several retinal
abscesses.
Symptoms and signs
The first symptom of this disease is usually a slow loss of vision, especially that of night vision, making it harder to drive in the dark. Later signs include loss of peripheral vision, leading to tunnel vision. In some cases, symptoms are experienced in only one of the eyes. Experiencing floaters, flashes, blurred vision and loss of side vision in just one eye may be an early indication of onset of retinitis.
Diagnosis
Although there has been extensive research in the past decades on the disease, there is still no evidence-based therapies for this condition which is often diagnosed at an early age, usually in teenagers or young adults.
To make a specific diagnosis, intraocular fluid samples may be taken and sent for analysis. In some cases, blood or cerebrospinal fluid (CSF) are also tested. Imaging may be done to help make the diagnosis.
Prevention
Research indicates that some supplements, especially vitamin A, lutein, and omega-3 fatty acids, may slow down the progression of the disease and alleviate symptoms temporarily.
Treatment
It is extremely important to see an eye doctor regularly. While supplements mentioned above may help reduce the symptoms, retinitis itself is not curable. Additionally, devices such as low-vision magnifiers can be used to aid vision in patients with despaired vision due to retinitis. Rehabilitation services may also aid the patient so that patients may use their vision in a more effective way. Lastly, it is advisable to wear sunglasses even on gloomy days to protect the eyes from UV radiation.
Recent research
Current research on retinitis includes studying stem cells, medications, gene therapies,
and transplants to help treat/cure this condition. One study including patients with retinitis was conducted by using gene therapy.
References
* Retinitis. (n.d.). Retrieved December 12, 2017, from https://www.webmd.com/eye-health/retinitis-types-symptoms-treatment#1
* Parmeggiani, F. (2011). Clinics, Epidemiology and Genetics of Retinitis Pigmentosa. ''Current Genomics'', ''12''(4), 236–237. http://doi.org/10.2174/138920211795860080
External links
{{Authority control
Disorders of choroid and retina