Regulator of G-protein signaling 7 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''RGS7''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled
GPCR
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related ...
. RGS7 is a
GTPase-activating protein GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. GAPs are a ...
(GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.
Interactions
RGS7 has been shown to
interact with:
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GNB5
Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the ''GNB5'' gene. Alternatively spliced transcript variants encoding different isoforms exist.
Function
Heterotrimeric guanine nucleotide-binding pro ...
,
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GPR158,
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GPR179,
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PKD1
Polycystin 1 (PC1) is a protein that in humans is encoded by the ''PKD1'' gene. Mutations of ''PKD1'' are associated with most cases of autosomal dominant polycystic kidney disease, a severe hereditary disorder of the kidneys characterised by ...
,
and
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SNAPAP
SNARE-associated protein Snapin is a protein that in humans is encoded by the ''SNAPIN'' gene.
Function
SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. SNAPAP is also a componen ...
.
References
Further reading
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