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''Pseudoviridae'' is a family of viruses, which includes three genera. Viruses of the family are actually LTR retrotransposons of the Ty1-copia family. They replicate via structures called virus-like particles (VLPs). VLPs are not infectious like normal virions, but they nevertheless make up an essential part of the pseudoviral lifecycle.


Taxonomy

''Pseudoviridae'' is unofficially classified under group VI RNA Reverse Transcribing Viruses and infect fungi and
invertebrates Invertebrates are a paraphyletic group of animals that neither possess nor develop a vertebral column (commonly known as a ''backbone'' or ''spine''), derived from the notochord. This is a grouping including all animals apart from the chordate ...
. ''Pseudoviridae'' comprises highly divergent members and most ''Pseudoviridae'' encode Gag and Pol on a single open reading frame. ''Pseudoviridae'' is included in the order ''Ortervirales'' along with families ''
Belpaoviridae ''Semotivirus'' is the only genus of viruses in the family ''Belpaoviridae'' (formerly included in the family ''Metaviridae''). Species exist as retrotransposons in a eukaryotic Eukaryotes () are organisms whose cells have a nucleus. All ...
'', ''
Metaviridae ''Metaviridae'' is a family of viruses which exist as Ty3-gypsy LTR retrotransposons in a eukaryotic host's genome. They are closely related to retroviruses: members of the family ''Metaviridae'' share many genomic elements with retroviruses, in ...
'', ''
Retroviridae A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. Once inside the host cell's cytoplasm, the virus uses its own reverse transcriptase ...
'', and ''
Caulimoviridae ''Caulimoviridae'' is a family of viruses infecting plants. There are 94 species in this family, assigned to 11 genera. Viruses belonging to the family ''Caulimoviridae'' are termed double-stranded DNA (dsDNA) reverse-transcribing viruses (or pa ...
''. The family includes the following genera: * '' Hemivirus'' * '' Pseudovirus'' * '' Sirevirus'' Further ''Pseudoviridae'' species not classified into a genus are: * ''Penicillium camemberti virus - GP1''NCBI
Penicillium camemberti virus - GP1
(species)
* '' Phaseolus vulgaris Tpv2-6 virus''


Genome

The genome of viruses from this family is unsegmented, -RT, positive-sense, single-stranded RNA and is 4200–9700
nucleotides Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules with ...
long. The genome encodes structural proteins and non-structural proteins which codes for an RNA-dependent DNA polymerase, replicase, and reverse transcriptase for the
reverse transcription A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their genomes, ...
step during replication.


Virology

The viral capsid is unenveloped and looks roughly spherical. The capsid is round with icosahedral symmetry with triangulation number (T) = 3 and 4. It is also
isometric The term ''isometric'' comes from the Greek for "having equal measurement". isometric may mean: * Cubic crystal system, also called isometric crystal system * Isometre, a rhythmic technique in music. * "Isometric (Intro)", a song by Madeon from ...
to quasi-isometric and has a diameter of 30-50 nm. LTR-
retrotransposons Retrotransposons (also called Class I transposable elements or transposons via RNA intermediates) are a type of genetic component that copy and paste themselves into different genomic locations ( transposon) by converting RNA back into DNA throug ...
are poorly characterized and lipids have not reported. The genome integrates into the host genome and gets transcribed by host cell
enzymes Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. ...
such as eukaryotic nuclear RNA polymerase II. Genome replication takes place in the host
cytoplasm In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. Th ...
, or the
nucleus Nucleus ( : nuclei) is a Latin word for the seed inside a fruit. It most often refers to: * Atomic nucleus, the very dense central region of an atom *Cell nucleus, a central organelle of a eukaryotic cell, containing most of the cell's DNA Nucl ...
and assembly can occur in the cytoplasm, or in the nucleus.


References


External links


ICTV Report: ''Pseudoviridae''Pseudoviridae
(Darwin Zoology) {{Taxonbar, from=Q3772842 RNA reverse-transcribing viruses Virus families Ortervirales