Precorrin-3B C17-methyltransferase
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In
enzymology An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
, precorrin-3B C17-methyltransferase () is an
enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that catalyzes the
chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
:S-adenosyl-L-methionine + precorrin-3B \rightleftharpoons S-adenosyl-L-homocysteine + precorrin-4 : The two substrates of this enzyme are S-adenosyl methionine and precorrin 3B, and its two products are S-adenosylhomocysteine and precorrin 4. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...
of this enzyme class is S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase. Other names in common use include precorrin-3 methyltransferase, and CobJ. This enzyme is part of the biosynthetic pathway to
cobalamin Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. One of eight B vitamins, it serves as a vital cofactor (biochemistry), cofactor in DNA synthesis and both fatty acid metabolism, fatty acid and amino a ...
(vitamin B12) in aerobic
bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micr ...
and during this step the macrocycle ring-contracts so that the corrin core of the vitamin is formed.


See also

*
Cobalamin biosynthesis Cobalamin biosynthesis is the process by which bacteria and archea make Vitamin B12, cobalamin, vitamin B12. Many steps are involved in converting aminolevulinic acid via uroporphyrinogen III and adenosylcobyric acid to the final forms in which i ...


References

* * EC 2.1.1 Enzymes of unknown structure {{2.1-enzyme-stub