POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription (genetics), transcription of genetics, genetic information from DNA to messenger RNA, by binding t ...
for
growth hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in ...
encoded by the gene ''POU1F1''.
Function
PIT1 is part of the
POU family of transcription factors. It is expressed by
somatotrophic cells,
as well as
thyrotrophs
and
lactotrophs
of the anterior pituitary gland. It contains a C-terminal domain for transactivation.
[ Another domain is DNA binding—its C-terminal portion is homologous to the homeodomain consensus,][ common to many genes involved in development, while the other portion is POU specific, affords PIT1 specificity in its transcriptional activation of the ]prolactin
Prolactin (PRL), also known as lactotropin and mammotropin, is a protein best known for its role in enabling mammals to produce milk. It is influential in over 300 separate processes in various vertebrates, including humans. Prolactin is secr ...
and growth hormone genes and is involved in protein-protein interactions.[ Activity on thyroid stimulating hormone-beta expression is also known for PIT1.][
]
Interactions
Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2
References
Further reading
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External links
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POU-domain proteins
{{biochemistry-stub