NIM811 is a

mitochondrial permeability transition The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP, or MTP) is a protein pore complex that forms in the inner mitochondrial membrane under certain pathological conditions such as traumatic brain injury, isch ...

inhibitor. Also known as ''N''-methyl-4-isoleucine cyclosporin, it is a substituted cyclosporine

analog Analog or analogue may refer to: Computing and electronics * Analog signal, in which information is encoded in a continuous variable ** Analog device, an apparatus that operates on analog signals *** Analog electronics, circuits which use analog ...

that binds to cyclophilin; however, this binary complex cannot bind to calcineurin, and therefore lacks immunosuppressive activity. NIM811 is a form of treatment for patients with the

hepatitis C virus The hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ''Flaviviridae''. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepatoc ...

(HCV). Studies indicate a strong relationship between a treatment's cyclophilin binding affinity and suppression of HCV activity. NIM811 is also being studied as a potential treatment to genetic muscular diseases such as

Ullrich congenital muscular dystrophy Ullrich congenital muscular dystrophy (UCMD) is a form of congenital muscular dystrophy. There are two forms: UCMD1 and UCMD2. UCMD1 is associated with variants of type VI collagen, while UCMD2 is associated with variants of type XII collagen. UC ...

(UCMD) and

Bethlem myopathy Bethlem myopathy is predominantly an autosomal dominant myopathy, classified as a congenital form of limb-girdle muscular dystrophy. There are two types of Bethlem myopathy, based on which type of collagen is affected. Bethlem myopathy 1 (BTHLM1) ...

(BM) disease, diseases altering the genes for collagen VI production.

References

{{Reflist Cyclic peptides Macrocycles Hendecapeptides