Middle East blind mole rat
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The Middle East blind mole-rat (''Nannospalax ehrenbergi''), also known as the Palestine mole-rat or Ehrenberg's mole-rat, is a species of
rodent Rodents (from Latin , 'to gnaw') are mammals of the Order (biology), order Rodentia ( ), which are characterized by a single pair of continuously growing incisors in each of the upper and Mandible, lower jaws. About 40% of all mammal specie ...
in the family
Spalacidae The Spalacidae, or spalacids, are a family of rodents in the large and complex superfamily Muroidea. They are native to eastern Asia, the Horn of Africa, the Middle East, and southeastern Europe. It includes the blind mole-rats, bamboo rats, m ...
.


Taxonomy

It was formerly classified in the genus ''
Spalax ''Spalax'' is a genus of rodent in the family Spalacidae, subfamily Spalacinae (blind mole-rats). It is one of two extant genera in the subfamily Spalacinae, alongside '' Nannospalax''.' Species in this genus are found in eastern Europe an ...
'', but more recent phylogenetic evidence supports it and two other species belonging to the genus '' Nannospalax''. Of the three ''Nannospalax'' species, ''N. ehrenbergi'' is the only one to also belong to the
subgenus In biology, a subgenus ( subgenera) is a taxonomic rank directly below genus. In the International Code of Zoological Nomenclature, a subgeneric name can be used independently or included in a species name, in parentheses, placed between the ge ...
''Nannospalax'' (unless the potential species within ''N. ehrenbergi'' are also considered their own species). The species name, ''ehrenbergi'', honors German naturalist
Christian Gottfried Ehrenberg Christian Gottfried Ehrenberg (19 April 1795 – 27 June 1876) was a German Natural history, naturalist, zoologist, Botany, botanist, comparative anatomist, geologist, and microscopy, microscopist. He is considered to be one of the most famous an ...
, who conducted significant research throughout the Middle East in the 19th century.


Possible cryptic species

Cytogenetic Cytogenetics is essentially a branch of genetics, but is also a part of cell biology/cytology (a subdivision of human anatomy), that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis an ...
studies have shown ''N. ehrenbergi'' in Israel may actually be a
species complex In biology, a species complex is a group of closely related organisms that are so similar in appearance and other features that the boundaries between them are often unclear. The taxa in the complex may be able to hybridize readily with each oth ...
containing several
cryptic species In biology, a species complex is a group of closely related organisms that are so similar in appearance and other features that the boundaries between them are often unclear. The taxa in the complex may be able to hybridize readily with each oth ...
with
chromosome number Ploidy () is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes. Here ''sets of chromosomes'' refers to the number of maternal and paternal chromosome copies, ...
s 2n=52, 2n=54, 2n=58 and 2n=60. Close to the 'border line' of the niche of each subspecies there is mating between individuals from different subspecies/different 2n chromosome number. Birth of fertile offspring implies that
speciation Speciation is the evolutionary process by which populations evolve to become distinct species. The biologist Orator F. Cook coined the term in 1906 for cladogenesis, the splitting of lineages, as opposed to anagenesis, phyletic evolution within ...
of the subspecies has not been completed. In 2001, four new ''Nannospalax'' species (then classified within ''Spalax'')
endemic Endemism is the state of a species being found only in a single defined geographic location, such as an island, state, nation, country or other defined zone; organisms that are indigenous to a place are not endemic to it if they are also foun ...
to geographical regions within
Israel Israel, officially the State of Israel, is a country in West Asia. It Borders of Israel, shares borders with Lebanon to the north, Syria to the north-east, Jordan to the east, Egypt to the south-west, and the Mediterranean Sea to the west. Isr ...
,
Palestine Palestine, officially the State of Palestine, is a country in West Asia. Recognized by International recognition of Palestine, 147 of the UN's 193 member states, it encompasses the Israeli-occupied West Bank, including East Jerusalem, and th ...
and the
Golan Heights The Golan Heights, or simply the Golan, is a basaltic plateau at the southwest corner of Syria. It is bordered by the Yarmouk River in the south, the Sea of Galilee and Hula Valley in the west, the Anti-Lebanon mountains with Mount Hermon in t ...
were described based on chromosome divergence by a team of researchers led by Eviatar Nevo. These were: * The Mount Carmel blind mole-rat (''N. carmeli'') - endemic to
Mount Carmel Mount Carmel (; ), also known in Arabic as Mount Mar Elias (; ), is a coastal mountain range in northern Israel stretching from the Mediterranean Sea towards the southeast. The range is a UNESCO biosphere reserve. A number of towns are situat ...
in northern Israel, including the vicinity of Afik, Kabri, and Tzippori settlements. * The Upper Galilee Mountains blind mole rat (''N. galili'') - endemic to
Upper Galilee The Upper Galilee (, ''HaGalil Ha'Elyon''; , ''Al Jaleel Al A'alaa'') is a geographical region located in northern Israel and southern Lebanon. Part of the larger Galilee region, it is characterized by its higher elevations and mountainous terra ...
in northern Israel, including the vicinity of Kerem Ben Zimra settlement. * The Golan Heights blind mole-rat (''N. golani'') - endemic to the Golan Heights, including the vicinity of
Mount Hermon Mount Hermon ( / ALA-LC: ('Mountain of the Sheikh', ), , ) is a mountain, mountain cluster constituting the southern end of the Anti-Lebanon mountain range. Its summit straddles the Lebanon–Syria border, border between Syria and Lebanon a ...
, Quneitra and Eliad. * The Judean Mountains blind mole-rat (''N. judaei'') - endemic to the Judaean Mountains in central Israel and Palestine, including the vicinity of
Kibbutz A kibbutz ( / , ; : kibbutzim / ) is an intentional community in Israel that was traditionally based on agriculture. The first kibbutz, established in 1910, was Degania Alef, Degania. Today, farming has been partly supplanted by other economi ...
Lahav Lahav () is a kibbutz in southern Israel. Located around 20 km north of Beersheba and covering 33,000 dunams, it falls under the jurisdiction of Bnei Shimon Regional Council. In it had a population of . History The kibbutz was established ...
. Although the
ITIS The Integrated Taxonomic Information System (ITIS) is an American partnership of federal agencies designed to provide consistent and reliable information on the taxonomy of biological species. ITIS was originally formed in 1996 as an interagenc ...
and
Mammal Species of the World ''Mammal Species of the World: A Taxonomic and Geographic Reference'' is a standard reference work in mammalogy giving descriptions and Bibliographic database, bibliographic data for the known species of mammals. It is now in its third edition, ...
still recognize these species, the
American Society of Mammalogists The American Society of Mammalogists (ASM) was founded in 1919. Its primary purpose is to encourage the study of mammal A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence ...
and the
IUCN Red List The International Union for Conservation of Nature (IUCN) Red List of Threatened Species, also known as the IUCN Red List or Red Data Book, founded in 1964, is an inventory of the global conservation status and extinction risk of biological ...
presently group these within ''N. ehrenbergi'' due to taxonomic uncertainty, such as lack of convincing genetic support for speciation, and the type locality of ''ehrenbergi'' itself likely falling within the range of one of these species.


Description

The Middle East blind mole-rat weighs . It has light gray fur and four sharp teeth, two large teeth in the upper jaw and two smaller teeth in the lower jaw. It has a life span of up to 20 years and is notable for its adaptability to severe lack of oxygen. In Israel, the blind mole-rat is a major agricultural pest. It digs long tunnels up to 80 centimeters deep and stores onions and tubers in underground chambers."Better check that mole: Has an Israeli biologist found the key to curing cancer?"
''
Haaretz ''Haaretz'' (; originally ''Ḥadshot Haaretz'' – , , ) is an List of newspapers in Israel, Israeli newspaper. It was founded in 1918, making it the longest running newspaper currently in print in Israel. The paper is published in Hebrew lan ...
''
The exceptional ecological adaptation strategies of the blind mole-rats can be seen in their different tongue morphologies, as evidenced by their tongue papillae. The tongue papillae differ between individuals in a species to adapt to different environmental regions with variant soil characteristics and food types.


Distribution and habitat

''N. ehrenbergi'' is found in
Egypt Egypt ( , ), officially the Arab Republic of Egypt, is a country spanning the Northeast Africa, northeast corner of Africa and Western Asia, southwest corner of Asia via the Sinai Peninsula. It is bordered by the Mediterranean Sea to northe ...
,
Iraq Iraq, officially the Republic of Iraq, is a country in West Asia. It is bordered by Saudi Arabia to Iraq–Saudi Arabia border, the south, Turkey to Iraq–Turkey border, the north, Iran to Iran–Iraq border, the east, the Persian Gulf and ...
,
Turkey Turkey, officially the Republic of Türkiye, is a country mainly located in Anatolia in West Asia, with a relatively small part called East Thrace in Southeast Europe. It borders the Black Sea to the north; Georgia (country), Georgia, Armen ...
and the
Levant The Levant ( ) is the subregion that borders the Eastern Mediterranean, Eastern Mediterranean sea to the west, and forms the core of West Asia and the political term, Middle East, ''Middle East''. In its narrowest sense, which is in use toda ...
(
Israel Israel, officially the State of Israel, is a country in West Asia. It Borders of Israel, shares borders with Lebanon to the north, Syria to the north-east, Jordan to the east, Egypt to the south-west, and the Mediterranean Sea to the west. Isr ...
,
Syria Syria, officially the Syrian Arab Republic, is a country in West Asia located in the Eastern Mediterranean and the Levant. It borders the Mediterranean Sea to the west, Turkey to Syria–Turkey border, the north, Iraq to Iraq–Syria border, t ...
,
Palestine Palestine, officially the State of Palestine, is a country in West Asia. Recognized by International recognition of Palestine, 147 of the UN's 193 member states, it encompasses the Israeli-occupied West Bank, including East Jerusalem, and th ...
,
Jordan Jordan, officially the Hashemite Kingdom of Jordan, is a country in the Southern Levant region of West Asia. Jordan is bordered by Syria to the north, Iraq to the east, Saudi Arabia to the south, and Israel and the occupied Palestinian ter ...
and
Lebanon Lebanon, officially the Republic of Lebanon, is a country in the Levant region of West Asia. Situated at the crossroads of the Mediterranean Basin and the Arabian Peninsula, it is bordered by Syria to the north and east, Israel to the south ...
). The natural
habitat In ecology, habitat refers to the array of resources, biotic factors that are present in an area, such as to support the survival and reproduction of a particular species. A species' habitat can be seen as the physical manifestation of its ...
of the mole is Mediterranean-type shrubbish vegetation, and it is threatened by
habitat loss Habitat destruction (also termed habitat loss or habitat reduction) occurs when a natural habitat is no longer able to support its native species. The organisms once living there have either moved elsewhere, or are dead, leading to a decrease ...
.


Use in research

According to Israeli researchers at Haifa University, the Middle East blind mole-rat is an important lab animal for researching cancer due to its apparent resistance to the disease. In a 2013 study, data on ''N. ehrenbergi'' resistance to cancer was documented: -No spontaneous tumors have ever been noticed in blind mole rat, based on observing thousands of individuals along half a century. -Inducing cancer with chemical carcinogens that lead to 100% of the expected tumors in mice and rats after 2–6 months, respectively, indicate an extraordinary cancer resistance of Spalax: Only 2 out of 12 animals, and old ones (>10 years old; Spalax can live ~>20 years; 5 times longer than its evolutionary relative, the rat) developed the expected tumor with one of the carcinogens and only after 18 and 30 months. - ''Nannospalax'' cells (
fibroblast A fibroblast is a type of cell (biology), biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework (Stroma (tissue), stroma) for animal Tissue (biology), tissues, and ...
s), and only ''Nannospalax'' cells, when grown in co-culture with cancer cells from different species, including a wide range of human cancer cells, kill the cancer cells. This is also true when "feeding" the cancer cells with the medium that ''Nannospalax'' cells grew in. Identification of the secreted substance/s by ''Nannospalax'' fibroblasts and the component on cancer cells' membrane they interact with, that lead to the cancer cells' death, can open a possibility for finding a general cure to cancer. Cancer resistance has also been noted in the two former species (''N. judaei'' and ''N. golani'') presently merged with this species. ''N. galili'' had its genome sequenced in 2014. Studies on the growth of
fibroblast A fibroblast is a type of cell (biology), biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework (Stroma (tissue), stroma) for animal Tissue (biology), tissues, and ...
s ''
in vitro ''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in ...
'' of ''N. judaei'' and ''N. golani'' showed that the process of
necrosis Necrosis () is a form of cell injury which results in the premature death of cells in living tissue by autolysis. The term "necrosis" came about in the mid-19th century and is commonly attributed to German pathologist Rudolf Virchow, who i ...
replaces the role of the systematic
apoptosis Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biol ...
normally used in most organisms. Generally low-oxygen conditions, such as those common in blind mole rats’ burrows, usually cause cells to undergo apoptosis. One study showed that in adaptation to a higher tendency of cell death, blind mole rats evolved a mutation in the
tumor suppressor A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell (biology), cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results ...
protein
p53 p53, also known as tumor protein p53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins (originally thou ...
, also used in humans, to prevent cells from undergoing apoptosis. Human cancer patients have similar mutations, and blind mole rats were thought to be more susceptible to cancer because their cells cannot undergo apoptosis. However, after a specific amount of time (within 3 days according to one study), the cells in blind mole rats release
interferon-beta The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cyt ...
(which the immune system normally uses to counter viruses) in response to over-proliferation of cells caused by the suppression of apoptosis. In this case, the interferon-beta triggers cells to undergo necrosis, and this mechanism also kills cancer cells in blind mole rats. Because of tumor suppression mechanisms such as this, blind mole rats and other spalacids are resistant to cancer. The involvement of interferon in the so-called concerted cell death of Spalax cells via necrosis was highly disputed. Serious questions have been raised on the inconsistent methodology used that led to this speculation. Observing the dirt displaced by burrowing mole rats can help archaeologists decide where to dig, since it often contains small artifacts like
potsherd This page is a glossary of archaeology, the study of the human past from material remains. A B C D E F ...
s.


See also

* Wildlife of Israel


References

{{Taxonbar, from=Q13422405, from2=Q34486739 Nannospalax Mammals of the Middle East Mammals described in 1898 Taxonomy articles created by Polbot