In biochemistry, the metallome is the distribution of

metal A metal (from ancient Greek, Greek μέταλλον ''métallon'', "mine, quarry, metal") is a material that, when freshly prepared, polished, or fractured, shows a lustrous appearance, and conducts electrical resistivity and conductivity, e ...

ions An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by conven ...

in a cellular compartment. The term was coined in analogy with

proteome The proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. ...

as metallomics is the study of metallome: the "comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type". Therefore, metallomics can be considered a branch of

metabolomics Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprin ...

, even though the metals are not typically considered as

metabolites In biochemistry, a metabolite is an intermediate or end product of metabolism. The term is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, ...

. An alternative definition of "metallomes" as

metalloprotein Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large proportion of all proteins are part of this category. For instance, at least 1000 human proteins (out of ~20,000) contain zinc-binding protein domains al ...

s or any other metal-containing

biomolecules A biomolecule or biological molecule is a loosely used term for molecules present in organisms that are essential to one or more typically biological processes, such as cell division, morphogenesis, or development. Biomolecules include lar ...

, and "metallomics" as a study of such biomolecules.

Metallointeractome

In the study of metallomes the

transcriptome The transcriptome is the set of all RNA transcripts, including coding and non-coding, in an individual or a population of cells. The term can also sometimes be used to refer to all RNAs, or just mRNA, depending on the particular experiment. The t ...

, proteome and the

metabolome The metabolome refers to the complete set of Small molecule, small-molecule chemicals found within a biological sample. The biological sample can be a Cell (biology), cell, a cellular organelle, an Organ (anatomy), organ, a Tissue (biology), tiss ...

constitutes the whole metallome. A study of the metallome is done to arrive at the metallointeractome.

Metallotranscriptome

The metallotranscriptome can be defined as the map of the entire transcriptome in the presence of biologically or environmentally relevant concentrations of an essential or toxic metal, respectively. The metallometabolome constitutes the complete pool of small metabolites in a cell at any given time. This gives rise to the whole metallointeractome and knowledge of this is important in comparative metallomics dealing with toxicity and drug discovery.

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* electronic-book electronic- * * * * * * {{refend Systems biology Metabolism Bioinformatics Biochemistry methods

Metallointeractome

Metallotranscriptome

See also

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