''Muromegalovirus'' is a genus of
viruses
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are found in almo ...
in the order ''
Herpesvirales
''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans cause ...
'', in the family ''
Herpesviridae
''Orthoherpesviridae'', previously named and more widely known as ''Herpesviridae'', is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are commonly known as herp ...
'', in the subfamily ''
Betaherpesvirinae
''Betaherpesvirinae'' is a subfamily of viruses in the order '' Herpesvirales'' and in the family ''Herpesviridae''. Mammals serve as natural hosts. There are 26 species in this subfamily, divided among 5 genera. Diseases associated with this su ...
''. Rodents serve as
natural hosts. There are three species in this genus. Diseases associated with this genus include: infected peritoneal macrophages, dendritic cells (DC) and hepatocytes, inducing significant pathology in both the spleen and the liver.
Murid
In Sufism, a (Arabic ) is a novice committed to spiritual enlightenment by (traversing a path) under a spiritual guide, who may take the title , or . A or Sufi follower only becomes a when he makes a pledge () to a . The equivalent Pers ...
viruses ''
Murid betaherpesvirus 1'' (MuHV-1) and ''
Murid betaherpesvirus 2'' (MuHV-2), previously defined as mouse
cytomegalovirus
''Cytomegalovirus'' (CMV) (from ''cyto-'' 'cell' via Greek - 'container' + 'big, megalo-' + -''virus'' via Latin 'poison') is a genus of viruses in the order '' Herpesvirales'', in the family '' Herpesviridae'', in the subfamily '' Betaherp ...
(MCMV) and rat cytomegalovirus (RCMV), belong to this genus.
Species
The following 3 species are assigned to the genus in ICTV 2022:
* ''
Muromegalovirus muridbeta1''
* ''
Muromegalovirus muridbeta2''
* ''
Muromegalovirus muridbeta8''
Structure
Viruses in ''Muromegalovirus'' are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 230kb in length.
Life cycle
Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding.
Rodents serve as the natural host.
References
External links
Viralzone: ''Muromegalovirus''ICTV
{{Use dmy dates, date=April 2017
Betaherpesvirinae
Animal viral diseases
Virus genera
Rodent diseases