Modafiendz, also known as ''N''-methyl-4,4-difluoromodafinil or as ''N''-methylbisfluoromodafinil, is a

wakefulness-promoting agent Eugeroics (originally "eugrégorique" or "eugregoric"), also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness. They are medically indicated for the treatment of cer ...

related to

modafinil Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant medication used to treat sleepiness due to narcolepsy, shift work sleep disorder, and obstructive sleep apnea. While it has seen off-label ...

that was never marketed. It is sold online and used non-medically as a

nootropic Nootropics ( , or ) ( colloquial: smart drugs and cognitive enhancers, similar to adaptogens) are a wide range of natural or synthetic supplements or drugs and other substances that are claimed to improve cognitive function or to promote re ...

(cognitive enhancer). Modafiendz is the ''bis''-

fluoro Fluorine is a chemical element with the symbol F and atomic number 9. It is the lightest halogen and exists at standard conditions as a highly toxic, pale yellow diatomic gas. As the most electronegative reactive element, it is extremely reactive ...

and ''N''- methylated

derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...

of modafinil as well as the ''N''-methyl analogue of

flmodafinil CRL-40,940 (also known as flmodafinil, bisfluoromodafinil and lauflumide) is the bisfluoro analog of modafinil. It is a eugeroic as well as a weak dopamine reuptake inhibitor. Its inventors claim that it is more effective than modafinil and adraf ...

(CRL-40,940; bisfluoromodafinil) and fladrafinil (CRL-40,941; bisfluoroadrafinil). Modafinil and its analogues have been found to act as selective

dopamine reuptake inhibitor A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular do ...

s and this is thought to be involved in their wakefulness-promoting effects.

References

4-Fluorophenyl compounds Acetamides Designer drugs Drugs with unknown mechanisms of action Experimental drugs Nootropics Stimulants Sulfoxides Wakefulness-promoting agents Modafinil analogues {{Nervous-system-drug-stub

See also

References