Minor Jesser Coon (July 29, 1921 – September 5, 2018) was an American

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

and Victor V Vaughan Distinguished University Professor

Emeritus ''Emeritus/Emerita'' () is an honorary title granted to someone who retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus". In some c ...

at the

University of Michigan, Ann Arbor The University of Michigan (U-M, U of M, or Michigan) is a public research university in Ann Arbor, Michigan, United States. Founded in 1817, it is the oldest institution of higher education in the state. The University of Michigan is one of th ...

. He is best known for his research on

cytochrome P-450 Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases. However, they are not omnipresent; for example, they have not been found in ''Escherichi ...

and as the co-discoverer of

HMG-CoA β-Hydroxy β-methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3-methylglutaryl coenzyme A, is an intermediate in the mevalonate pathway, mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase ...

, along with Bimal Kumar Bachhawat. He died on September 5, 2018, from complications due to

Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...

Early life and education

Coon was born in

Englewood, Colorado The City of Englewood is a home rule municipality located in Arapahoe County, Colorado, United States. The town population was 33,659 at the 2020 United States census. Englewood is a part of the Denver–Aurora–Lakewood, CO Metropolitan S ...

, in 1921. He was an

undergraduate Undergraduate education is education conducted after secondary education and before postgraduate education, usually in a college or university. It typically includes all postsecondary programs up to the level of a bachelor's degree. For example, ...

student at the

University of Colorado The University of Colorado (CU) is a system of public universities in Colorado. It consists of four institutions: the University of Colorado Boulder, the University of Colorado Colorado Springs, the University of Colorado Denver, and the U ...

and received his

bachelor's degree A bachelor's degree (from Medieval Latin ''baccalaureus'') or baccalaureate (from Modern Latin ''baccalaureatus'') is an undergraduate degree awarded by colleges and universities upon completion of a course of study lasting three to six years ...

with honors in 1943. He received his

Ph.D. A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

from the

University of Illinois at Urbana–Champaign The University of Illinois Urbana-Champaign (UIUC, U of I, Illinois, or University of Illinois) is a public land-grant research university in the Champaign–Urbana metropolitan area, Illinois, United States. Established in 1867, it is the f ...

in 1946, supervised by

William Cumming Rose William Cumming Rose (April 4, 1887 – September 25, 1985) was an American biochemist and nutritionist. He discovered the amino acid threonine, and his research determined the necessity for essential amino acids in diet and the minimum daily re ...

. During his graduate work he studied

amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...

metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...

and

nitrogen balance In human physiology, nitrogen balance is the net difference between bodily nitrogen intake (ingestion) and loss (excretion). It can be represented as the following: \mbox = - Nitrogen is a fundamental chemical component of amino acids, the mole ...

using himself and his fellow students as volunteer subjects.

Academic career

After a year as a

postdoctoral fellow A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academ ...

at the University of Illinois, Coon became a faculty member at the

University of Pennsylvania The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of f ...

in 1947. He moved to the

University of Michigan Medical School The University of Michigan Medicine (branded as Michigan Medicine) is the academic medical center of the University of Michigan, a public research university in Ann Arbor, Michigan. It consists of the university's Medical School, affiliated hos ...

in 1955 and remained there for the remainder of his career, chairing the biological chemistry department from 1970 to 1990 and becoming the Victor V. Vaughan Distinguished University Professor of Biological Chemistry in 1983. Coon served as the president of the

American Society for Biochemistry and Molecular Biology The American Society for Biochemistry and Molecular Biology (ASBMB) is a learned society that was founded on December 26, 1906, at a meeting organized by John Jacob Abel (Johns Hopkins University). The roots of the society were in the American Ph ...

from 1991 to 1992. He became a member of the

United States National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

in 1983 and a fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

in 1984. A biological chemistry professorship in his honor was established at the University of Michigan in 1991. Coon mentored many graduate students and promoted teaching along with research, including

David Ballou David P. Ballou is a professor emeritus of biological chemistry at the University of Michigan Medical School in the United States. He is best known for his development of rapid-reaction techniques, including stopped flow and rapid freeze-quench ...

and Professor Emeritus Tetsufumi Ueda, a pioneer in neuroscience. The Minor J. and Mary Lou Coon Award was established by him and his wife, to recognize an outstanding graduate student in biological chemistry at the University of Michigan who excels at teaching, research, and service.

Interests

Coon was a patron of the arts.

Awards and honors

Coon has received a number of awards in recognition of his scientific achievements. *

Paul-Lewis Award in Enzyme Chemistry The Pfizer Award in Enzyme Chemistry, formerly known as the Paul-Lewis Award in Enzyme Chemistry was established in 1945. Consisting of a gold medal and honorarium, its purpose is to stimulate fundamental research in enzyme chemistry by scientists ...

, 1959 *

William C. Rose Award The William C. Rose Award given by the American Society for Biochemistry and Molecular Biology recognizes outstanding contributions to biochemical and molecular biological research and a demonstrated commitment to the training of younger scientists ...

in Biochemistry, 1978 * Bernard B. Brodie Award in Drug Metabolism, 1980 * Member,

, 1983 * Fellow,

, 1984 * Member,

Institute of Medicine The National Academy of Medicine (NAM), known as the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineerin ...

, 1987 *Honorary Doctor of Medicine,

Karolinska Institute The Karolinska Institute (KI; ; sometimes known as the (Royal) Caroline Institute in English) is a research-led medical university in Solna within the Stockholm urban area of Sweden and one of the foremost medical research institutes globally ...

References

{{DEFAULTSORT:Coon, Minor J. 1921 births 2018 deaths University of Michigan faculty Members of the United States National Academy of Sciences Fellows of the American Academy of Arts and Sciences Members of the National Academy of Medicine Deaths from Alzheimer's disease in Michigan Deaths from dementia in Michigan University of Colorado alumni University of Illinois Urbana-Champaign alumni People from Englewood, Colorado 20th-century American biochemists