Michael Gribskov is a professor of Biological Sciences and Computer Science at

Purdue University Purdue University is a Public university#United States, public Land-grant university, land-grant research university in West Lafayette, Indiana, United States, and the flagship campus of the Purdue University system. The university was founded ...

. In 1979, Gribskov graduated from

Oregon State University Oregon State University (OSU) is a Public university, public Land-grant university, land-grant research university in Corvallis, Oregon, United States. OSU offers more than 200 undergraduate degree programs and a variety of graduate and doctor ...

, with a Bachelor in Science Honors degree in Biochemistry and Biophysics. Later in 1985, he finished his PhD degree in Molecular Biology from

University of Wisconsin–Madison The University of Wisconsin–Madison (University of Wisconsin, Wisconsin, UW, UW–Madison, or simply Madison) is a public land-grant research university in Madison, Wisconsin, United States. It was founded in 1848 when Wisconsin achieved st ...

. He has served as president of the

International Society for Computational Biology The International Society for Computational Biology (ISCB) is a scholarly society for researchers in computational biology and bioinformatics. The society was founded in 1997 to provide a stable financial home for the Intelligent Systems for Mo ...

,History of ISCB
/ref> and his faculty page states that he is the chair of the

Protein Information Resource The Protein Information Resource (PIR), located at Georgetown University Medical Center, is an integrated public bioinformatics resource to support genomic and proteomic research, and scientific studies. It contains protein sequences databases H ...

Scientific Oversight and Advisory Board, and on the editorial boards of the journals ''

Bioinformatics Bioinformatics () is an interdisciplinary field of science that develops methods and Bioinformatics software, software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, ...

'', '' Journal of Computational Biology and Chemistry'', and '' Journal of Molecular Microbiology & Biotechnology''.Purdue University Faculty Profile

Profile analysis

Gribskov, along with

David Eisenberg David S. Eisenberg (born 15 March 1939) is an American biochemist and Biophysics, biophysicist best known for his contributions to structural biology and computational molecular biology. He has been a professor at the University of California, ...

and Andrew McLachlan, introduced the profile analysis method in 1987; this is a method for detecting distantly related proteins by sequence comparison. A profile is a position specific scoring matrix, and it is created from a group of sequences previously

aligned ''Aligned'' is a 2023 drama film written and directed by Apollo Bakopoulos. The film had its world premiere at the Brooklyn Film Festival The Brooklyn Film Festival (BFF), prior to 2011 called the Brooklyn International Film Festival (BiFF) is a ...

(probe). The similarity of any other sequence (target) (one or more than one) to the probe can be tested by comparing the target to the file using dynamic programming. This algorithm consists of two steps. The first step is the generation of the profile using software PROFWARE, which makes use of an existing alignment (probe) based on sequence similarity or the corresponding 3D structure to generate a profile. The second step is the comparison of the profile with a database of sequences or a single sequence. In this step, based on the profile generated, the target sequence or group of sequences could be aligned using PROFINAL, dynamic programming is used in the alignment.

References

{{DEFAULTSORT:Gribskov, Michael Living people Purdue University faculty Oregon State University alumni University of Wisconsin–Madison College of Letters and Science alumni Year of birth missing (living people)