Max Dale Cooper (born August 31, 1933), is an American immunologist and a

professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin ...

at the Department of

Pathology Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

and Laboratory Medicine and the Emory Vaccine Center of

Emory University Emory University is a private university, private research university in Atlanta, Georgia, United States. It was founded in 1836 as Emory College by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory. Its main campu ...

School of Medicine A medical school is a tertiary educational institution, professional school, or forms a part of such an institution, that teaches medicine, and awards a professional degree for physicians. Such medical degrees include the Bachelor of Medicine, ...

. He is known for characterizing

T cell T cells (also known as T lymphocytes) are an important part of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell ...

s and

B cell B cells, also known as B lymphocytes, are a type of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or inserted into the plasm ...

Early life and education

Cooper was born and raised in rural

Mississippi Mississippi ( ) is a U.S. state, state in the Southeastern United States, Southeastern and Deep South regions of the United States. It borders Tennessee to the north, Alabama to the east, the Gulf of Mexico to the south, Louisiana to the s ...

. His father was the Superintendent of Education of a 12-grade school in Bentonia and his mother a teacher. He lived with his family on the campus. He was interested in becoming a

physician A physician, medical practitioner (British English), medical doctor, or simply doctor is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through the Medical education, study, Med ...

at a young age, and his father, who wanted to study

medicine Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...

but could not due to financial reasons, encouraged him to do so. Cooper went to Holmes Junior College (now

Holmes Community College Holmes Community College is a public community college with its main campus in Goodman, Mississippi. It also has campuses in Grenada and Ridgeland, and satellite campuses in Attala, Webster, and Yazoo counties. Holmes Community College was ...

) on an

American football American football, referred to simply as football in the United States and Canada and also known as gridiron football, is a team sport played by two teams of eleven players on a rectangular American football field, field with goalposts at e ...

scholarship from 1951 to 1952, then entered the

University of Mississippi The University of Mississippi (Epithet, byname Ole Miss) is a Public university, public research university in University, near Oxford, Mississippi, United States, with a University of Mississippi Medical Center, medical center in Jackson, Miss ...

for

pre-medical Pre-medical (often referred to as pre-med) is an educational track that undergraduate students mostly in the United States pursue prior to becoming medical students. It involves activities that prepare a student for medical school, such as pre-med ...

studies. In 1954, Cooper started studying

at the

University of Mississippi School of Medicine The University of Mississippi School of Medicine (UMSOM) is the medical school of the University of Mississippi in the U.S. state of Mississippi. The UMSOM was created in 1903 on the Oxford campus. In 1955, it was moved from the Oxford campus ...

. Since the school at that time was a two-year

medical school A medical school is a tertiary educational institution, professional school, or forms a part of such an institution, that teaches medicine, and awards a professional degree for physicians. Such medical degrees include the Bachelor of Medicine, ...

and was becoming a four-year one, Cooper was offered the option of staying or transferring elsewhere. He chose to move to the

Tulane University The Tulane University of Louisiana (commonly referred to as Tulane University) is a private research university in New Orleans, Louisiana, United States. Founded as the Medical College of Louisiana in 1834 by a cohort of medical doctors, it b ...

, and obtained his MD in 1957.

Career

After graduating from

, Cooper interned at a hospital in

Saginaw Saginaw () is a city in Saginaw County, Michigan, United States, and its county seat. It had a population of 44,202 at the 2020 census. Located along the Saginaw River, Saginaw is adjacent to Saginaw Charter Township and considered part of ...

Michigan Michigan ( ) is a peninsular U.S. state, state in the Great Lakes region, Great Lakes region of the Upper Midwest, Upper Midwestern United States. It shares water and land boundaries with Minnesota to the northwest, Wisconsin to the west, ...

for a year, and then returned to

for a

residency Residency may refer to: * Artist-in-residence, a program to sponsor the residence and work of visual artists, writers, musicians, etc. * Concert residency, a series of concerts performed at one venue * Domicile (law), the act of establishing or m ...

. In 1960, Cooper went to Hospital for Sick Children, London as

pre-registration house officer Pre-registration house officer (PRHO), commonly referred to as house officer and less commonly as houseman, is a former official term for a grade of junior doctor that was, until 2005, the only job open to medical graduates in the United Kingdom ...

and then

research assistant A research assistant (RA) is a researcher employed, often on a temporary contract, by a university, research institute, or privately held organization to provide assistance in academic or private research endeavors. Research assistants work under ...

until 1961. From 1961 to 1962, he was a

pediatric Pediatrics (American English) also spelled paediatrics (British English), is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, pediatrics covers many of their youth ...

allergy Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...

and

immunology Immunology is a branch of biology and medicine that covers the study of Immune system, immune systems in all Organism, organisms. Immunology charts, measures, and contextualizes the Physiology, physiological functioning of the immune system in ...

fellow at the

University of California, San Francisco The University of California, San Francisco (UCSF) is a Public university, public Land-grant university, land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedic ...

. Cooper briefly returned to Tulane as an instructor, then moved to the Department of Pediatrics at the

University of Minnesota The University of Minnesota Twin Cities (historically known as University of Minnesota) is a public university, public Land-grant university, land-grant research university in the Minneapolis–Saint Paul, Twin Cities of Minneapolis and Saint ...

in 1963 to as a

medical Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...

fellow and instructor, working with Robert A. Good and conducting research. He became an

assistant professor Assistant professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States, Canada, Japan, and South Korea. Overview This position is generally taken after earning a doct ...

in 1966. One year later he joined the

University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) is a public research university in Birmingham, Alabama, United States. Founded in 1969 and part of the University of Alabama System, UAB has grown to be the state's largest employer, with more than ...

(UAB) as a

at the Division of Immunology and Allergy of the Department of Pediatrics and an

associate professor Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. In the ''North American system'', used in the United States and many other countries, it is a position ...

at the Department of

Microbiology Microbiology () is the branches of science, scientific study of microorganisms, those being of unicellular organism, unicellular (single-celled), multicellular organism, multicellular (consisting of complex cells), or non-cellular life, acellula ...

. Over the next few years, Cooper also became a professor at the Department of Microbiology, of

and of

Medicine Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...

. During this period, he was also involved with the Comprehensive

Cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...

Center (since 1971), the Multipurpose

Arthritis Arthritis is a general medical term used to describe a disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, Joint effusion, swelling, and decreased range of motion of ...

Center (since 1979), and the

Cystic Fibrosis Cystic fibrosis (CF) is a genetic disorder inherited in an autosomal recessive manner that impairs the normal clearance of Sputum, mucus from the lungs, which facilitates the colonization and infection of the lungs by bacteria, notably ''Staphy ...

Research Center (since 1981), all at UAB, and was an investigator at the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...

between 1988 and 2006. In 2008, convinced by the Georgia Research Alliance, where

is a partner institution, Cooper moved to the Department of Pathology and Laboratory Medicine at the

Georgia Georgia most commonly refers to: * Georgia (country), a country in the South Caucasus * Georgia (U.S. state), a state in the southeastern United States Georgia may also refer to: People and fictional characters * Georgia (name), a list of pe ...

, US. He is also a professor at the Winship Cancer Institute and the Emory Vaccine Center, and an Eminent Scholar at the Georgia Research Alliance. Cooper remains a

Professor Emeritus ''Emeritus/Emerita'' () is an honorary title granted to someone who retirement, retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus". ...

of Medicine at UAB. Cooper was the president of the

American Association of Immunologists American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, p ...

between 1988 and 1989 and a member of their Council from 1983 to 1988.

Research

Cooper's research focus is the

adaptive immune system The adaptive immune system (AIS), also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized cells, organs, and processes that eliminate pathogens specifically. The ac ...

, particularly

s and

s. Following Jacques Miller's discovery in 1961 of the

immunological Immunology is a branch of biology and medicine that covers the study of immune systems in all organisms. Immunology charts, measures, and contextualizes the physiological functioning of the immune system in states of both health and disease ...

role of the

thymus The thymus (: thymuses or thymi) is a specialized primary lymphoid organ of the immune system. Within the thymus, T cells mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders. The thymus ...

, the scientific community believed that there is only one lineage of

lymphocyte A lymphocyte is a type of white blood cell (leukocyte) in the immune system of most vertebrates. Lymphocytes include T cells (for cell-mediated and cytotoxic adaptive immunity), B cells (for humoral, antibody-driven adaptive immunity), an ...

s (the T cells), that produced by the thymus. As a

pediatrician Pediatrics (American English) also spelled paediatrics (British English), is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, pediatrics covers many of their youth ...

, Cooper was studying patients of the

Wiskott–Aldrich syndrome Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema, thrombocytopenia (low platelet count), immune deficiency, and bloody diarrhea (secondary to the thrombocytopenia). It is also sometimes called the e ...

, who have few lymphocytes but high levels of

plasma cell Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells and secrete large quantities of proteins called antibodies in response to being presented specific substances ca ...

s and

antibodies An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that caus ...

, which were thought to derive from T cells. Inspired by a report that the

bursa of Fabricius In birds, the bursa of Fabricius (Latin: ''bursa cloacalis'' or ''bursa Fabricii'') is the site of hematopoiesis. It is a specialized organ that, as first demonstrated by Bruce Glick and later by Max Dale Cooper and Robert Good, is necessary fo ...

(or the bursa) in

chicken The chicken (''Gallus gallus domesticus'') is a domesticated subspecies of the red junglefowl (''Gallus gallus''), originally native to Southeast Asia. It was first domesticated around 8,000 years ago and is now one of the most common and w ...

s may be responsible for producing antibodies, he conducted experiments in 1964 on chickens to determine the roles of the thymus and the bursa. He removed the thymus or the bursa from chicks and irradiated them with

X-ray An X-ray (also known in many languages as Röntgen radiation) is a form of high-energy electromagnetic radiation with a wavelength shorter than those of ultraviolet rays and longer than those of gamma rays. Roughly, X-rays have a wavelength ran ...

to kill lymphocytes that may have been produced earlier by the thymus and bursa. The experiments showed irradiated chicks with the bursa removed did not have plasma cells, antibodies, and

germinal center Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen – where mature B cells are activated, prolifera ...

s, despite their intact thymus. Conversely, irradiated chickens with the thymus removed had low lymphocyte levels, but had normal antibodies, plasma cells, and germinal centers. The lymphocytes produced by the bursa are known as

s. Again working on chickens, Cooper also made a contribution to deducing how B cells produce different types of antibodies at different stages of embryonic development, in the sequence of

IgM Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the first antibody to appear in the response to initial exposure to an antigen; causing it to also ...

IgG Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells. Each IgG ant ...

, and

IgA IGA or IgA may refer to: Businesses and organizations * IGA (supermarkets) (initially Independent Grocers Alliance), a name used by many independent supermarkets throughout the world ** IGA (Australian supermarket group), the local Australian v ...

. His experiments indicated a single lineage of B cells switch from IgM to producing other

immunoglobulin An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as pathogenic bacteria, bacteria and viruses, includin ...

isotypes, as opposed to multiple B cell subtypes each producing one immunoglobulin isotype. This process is known as

immunoglobulin class switching Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the ...

. Collaborating with John Owen from the UK, Cooper used a series of experiments to determine the

mammalian A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three ...

organ equivalent to the bursa and found that B cells are produced in the

liver The liver is a major metabolic organ (anatomy), organ exclusively found in vertebrates, which performs many essential biological Function (biology), functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of var ...

fetal A fetus or foetus (; : fetuses, foetuses, rarely feti or foeti) is the unborn offspring of a viviparous animal that develops from an embryo. Following the embryonic stage, the fetal stage of development takes place. Prenatal development is a ...

mice A mouse (: mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...

. Together with independent reports by Pierre Vassalli and

Gustav Nossal Sir Gustav Victor Joseph Nossal (born 4 June 1931) is an Austrian-born Australian research biologist. He is famous for his contributions to the fields of antibody formation and immunological tolerance. Early life and education Nossal's family w ...

in 1974 that B cells were produced in the

bone marrow Bone marrow is a semi-solid biological tissue, tissue found within the Spongy bone, spongy (also known as cancellous) portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). It i ...

of fetal mice, these discoveries show

haematopoietic Haematopoiesis (; ; also hematopoiesis in American English, sometimes h(a)emopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. In a healthy adult human, roughly ten b ...

tissues generate B cells in

mammal A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three ...

s. More recently, Cooper studied the

jawless vertebrates Agnatha (; ) or jawless fish is a paraphyletic infraphylum of animals in the subphylum Vertebrata of the phylum Chordata, characterized by the lack of jaws. The group consists of both extant taxon, living (Cyclostomi, cyclostomes such as hagfish ...

, including

lamprey Lampreys (sometimes inaccurately called lamprey eels) are a group of Agnatha, jawless fish comprising the order (biology), order Petromyzontiformes , sole order in the Class (biology), class Petromyzontida. The adult lamprey is characterize ...

s and

hagfish Hagfish, of the Class (biology), class Myxini (also known as Hyperotreti) and Order (biology), order Myxiniformes , are eel-shaped Agnatha, jawless fish (occasionally called slime eels). Hagfish are the only known living Animal, animals that h ...

. Working with Jan Klein, he confirmed these

animal Animals are multicellular, eukaryotic organisms in the Biology, biological Kingdom (biology), kingdom Animalia (). With few exceptions, animals heterotroph, consume organic material, Cellular respiration#Aerobic respiration, breathe oxygen, ...

s have cells functionally similar to mammalian T cells and B cells. Cooper's group also found that instead of antibodies, lampreys have a family of

immune receptor An immune receptor (or immunologic receptor) is a Receptor (biochemistry), receptor, usually on a cell membrane, which binds to a Ligand (biochemistry), ligand (usually another protein, such as cytokine) and causes a response in the immune system. ...

s. They named it variable lymphocyte receptor. Owing to the unique specificity of these antibody-counterparts and their distinction from human antibodies, they may be used in treating cancers such as

multiple myeloma Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibody, antibodies. Often, no symptoms are noticed initially. As it progresses, bone ...

and

brain cancer A brain tumor (sometimes referred to as brain cancer) occurs when a group of cells within the brain turn cancerous and grow out of control, creating a mass. There are two main types of tumors: malignant (cancerous) tumors and benign (non-cance ...

Awards and honors

* Member of the

American Society for Clinical Investigation The American Society for Clinical Investigation (ASCI), established in 1908, is one of the oldest and most respected medical honor societies in the United States. Organization and purpose The ASCI is an honorary society to which more than 2,800 p ...

(1972) * President's Medal,

(1988) * Member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

(1988) * Sandoz Prize for Immunology (1990) * Member of the Alabama Academy of Honor (1990) * Member of the

National Academy of Medicine The National Academy of Medicine (NAM), known as the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineerin ...

(1990) * Member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

(1992) *

Fellow A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...

of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsib ...

(1994) * American Association of Immunologists Lifetime Achievement Award (2000) * Robert Koch Award (2010) * Foreign Associate of the

French Academy of Sciences The French Academy of Sciences (, ) is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French Scientific method, scientific research. It was at the forefron ...

(2015) * Foreign Member of the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

(2017) *

Japan Prize is awarded to individuals whose original and outstanding achievements in science and technology are recognized as having advanced the frontiers of knowledge and served the cause of peace and prosperity for mankind. As of 2024, the Japan Prize h ...

(2018) * Distinguished Fellow of

(2019) *

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the Lasker Award, prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Phys ...

(2019) * Honorary Doctor of Medical Sciences from

Yale University Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United Stat ...

(2023)

References

{{DEFAULTSORT:Cooper, Max Dale American immunologists Members of the United States National Academy of Sciences Emory University School of Medicine faculty University of Mississippi alumni Tulane University School of Medicine alumni University of Alabama at Birmingham faculty University of Minnesota faculty University of California, San Francisco faculty 1933 births Living people People from Hazlehurst, Mississippi Foreign members of the Royal Society Members of the French Academy of Sciences Fellows of the American Academy of Arts and Sciences Fellows of the American Association for the Advancement of Science Members of the National Academy of Medicine Recipients of the Albert Lasker Award for Basic Medical Research