Manlio Vinciguerra (born 1976 in

Catania Catania (, , , Sicilian and ) is the second-largest municipality on Sicily, after Palermo, both by area and by population. Despite being the second city of the island, Catania is the center of the most densely populated Sicilian conurbation, wh ...

, Italy) is a scientist specializing in

epigenetics In biology, epigenetics is the study of changes in gene expression that happen without changes to the DNA sequence. The Greek prefix ''epi-'' (ἐπι- "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in ...

and aging research who held faculty positions at the Medical University of Varna, Bulgaria; at the International Clinical Research Center, Brno, Czech Republic; and at the University College London, United Kingdom. Vinciguerra received a doctorate in internal medicine in 2004, and also research training at the University of Geneva, Switzerland, and the European Molecular Biology Laboratory in Italy and in Germany (2005-2011). Vinciguerra obtained a degree in biomolecular sciences from the University of Catania, Italy, in 1999. Vinciguerra unraveled important cellular signaling and epigenetics mechanisms involved in metabolic processes, stress and

aging Ageing (or aging in American English) is the process of becoming Old age, older until death. The term refers mainly to humans, many other animals, and fungi; whereas for example, bacteria, perennial plants and some simple animals are potentiall ...

in the heart and in the liver, such as the

PI3K/AKT/mTOR pathway The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates ...

histone variants Histone variants are proteins that substitute for the core canonical histones ( H3, H4, H2A, H2B) in nucleosomes in eukaryotes and often confer specific structural and functional features. The term might also include a set of linker histone (H1 ...

and

sirtuin Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. Chemically, sirtuins are a class of proteins ...

s, using a

systems biology Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological system ...

approach in cells and rodent models. He is a member of ''Who's Who in Gerontology''.

References

{{DEFAULTSORT:Vinciguerra, Manlio People from Catania 1976 births Living people