Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''MAGI1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The protein encoded by this gene is a member of the
membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.
Interactions
MAGI1 has been shown to
interact with:
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ACCN3,
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ATN1,
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Actinin alpha 4,
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Beta-catenin
Catenin beta-1, also known as β-catenin (''beta''-catenin), is a protein that in humans is encoded by the ''CTNNB1'' gene.
β-Catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcrip ...
,
*
Brain-specific angiogenesis inhibitor 1,
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Calcium-activated potassium channel subunit alpha-1,
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FCHSD2
FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the ''FCHSD2'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides ...
,
*
LRP2,
and
*
SYNPO.
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References
Further reading
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{{PDB Gallery, geneid=9223