Mitotic spindle assembly checkpoint protein MAD2B is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''MAD2L2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.
Interactions
MAD2L2 has been shown to
interact with:
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ADAM9
Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ''ADAM9'' gene.
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this fami ...
,
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MAD2L1,
*
REV1,
and
*
REV3L.
References
Further reading
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