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Louis J. Ignarro (born May 31, 1941) is an American pharmacologist. For demonstrating the signaling properties of
nitric oxide Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula . It is one of the principal oxides of nitrogen. Nitric oxide is a free radical: it has an unpaired electron, which is sometimes denoted by a dot in its ...
, he was co-recipient of the 1998
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordi ...
with
Robert F. Furchgott Robert Francis Furchgott (June 4, 1916 – May 19, 2009) was a Nobel Prize-winning American biochemist who contributed to the discovery of nitric oxide as a transient cellular signal in mammalian systems. Early life and education Furchgott ...
and Ferid Murad. Currently, he is professor emeritus of
pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
at the UCLA School of Medicine's department of molecular and medical pharmacology in Los Angeles, which he joined in 1985. Before relocating to California, he was a professor of pharmacology at
Tulane University Tulane University, officially the Tulane University of Louisiana, is a private research university in New Orleans, Louisiana. Founded as the Medical College of Louisiana in 1834 by seven young medical doctors, it turned into a comprehensive pub ...
School of Medicine, New Orleans, for 12 years. Ignarro has also previously worked as a staff scientist, research department, for the pharmaceutical division of CIBA-GEIGY Corporation in New York. Ignarro has published numerous research articles. He received the Basic Research Prize of the
American Heart Association The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and deat ...
in 1998. This was in recognition of his outstanding contributions to the advancement of cardiovascular science. That same year, he was inducted into the National Academy of Sciences and the following year, into the American Academy of Arts and Sciences. Because nitric oxide is indirectly involved in the action of this drug, he is sometimes referred to as the "Father of Viagra". He is the founder of the Nitric Oxide Society, and founder and editor-in-chief of ''Nitric Oxide Biology and Chemistry.'' Ignarro holds a B.S. in pharmacy,
Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
, 1962, and a Ph.D. in pharmacology,
University of Minnesota The University of Minnesota, formally the University of Minnesota, Twin Cities, (UMN Twin Cities, the U of M, or Minnesota) is a public land-grant research university in the Twin Cities of Minneapolis and Saint Paul, Minnesota, United States. ...
, School of Medicine, 1966. He also received a postdoctoral fellowship in chemical pharmacology from
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the lat ...
in 1968. He is a member of the scientific committee of Nicox, a French pharmaceutical company, a member of the Board of Directors of Antibe Therapeutics, a Canadian drug discovery company, a member of the Board of Directors of
Operation USA Operation USA (also known as OpUSA, Operation California, or OpCal) is a non profit humanitarian organization supporting health, education and relief programs at home and abroad in order to help children and families recover and thrive in the wak ...
, a non-profit organization, and is past member of the Nutritional Advisory Board for
Herbalife Herbalife Nutrition Ltd., also called Herbalife International, Inc. (with a U.S. subsidiary called Herbalife International of America) or simply Herbalife, is a global multi-level marketing (MLM) corporation that develops and sells dietary su ...
, a multi-level marketing company.


Personal life

Louis J. Ignarro was born in 1941 in
Brooklyn, New York Brooklyn () is a borough of New York City, coextensive with Kings County, in the U.S. state of New York. Kings County is the most populous county in the State of New York, and the second-most densely populated county in the United States, be ...
. His parents were Italian immigrants and his father was a carpenter in Torre del Greco, near
Naples Naples (; it, Napoli ; nap, Napule ), from grc, Νεάπολις, Neápolis, lit=new city. is the regional capital of Campania and the third-largest city of Italy, after Rome and Milan, with a population of 909,048 within the city's adm ...
. Ignarro grew up in
Long Beach, NY Long Beach is an oceanfront city in Nassau County in New York, United States. It takes up a central section of the Long Beach Barrier Island, which is the westernmost of the outer barrier islands off Long Island's South Shore. As of the 2020 ...
, which is a suburb of
New York City, NY New York, often called New York City or NYC, is the most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the most densely populated major city in the Un ...
on the south shore of Long Island, NY. Ignarro received his first chemistry set as a gift at the age of 8. Ignarro is married to anesthesiologist Dr. Sharon Ignarro and lives in Beverly Hills, CA. He is an avid cyclist and marathoner, having completed 13 marathons. Ignarro has published multiple books for lay audiences about health and wellness focusing on the benefits of increasing nitric oxide production. He is a frequent public speaker on these and related topics.


Academic career

Ignarro attended Central Grade School and Long Beach High School. A strong interest in science led Ignarro to
Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
where he studied chemistry and pharmacology and in 1962 received a bachelor's degree in pharmacy from the Columbia University College of Pharmaceutical Sciences. Ignarro then attended the
University of Minnesota The University of Minnesota, formally the University of Minnesota, Twin Cities, (UMN Twin Cities, the U of M, or Minnesota) is a public land-grant research university in the Twin Cities of Minneapolis and Saint Paul, Minnesota, United States. ...
where he received a Ph.D. in pharmacology. His university studies also concentrated in chemistry, enzymology and cardiovascular physiology, which resulted in several published papers. While at the University of Minnesota, Ignarro studied under eventual Nobel Prize-winning chemist Paul Boyer. Ignarro's work continued at the NIH in the fields he'd studied, collaborating with many other scientists to discover regulatory mechanisms of the cardiovascular system that would lead to his most famous work. This was his first time to apply his education outside of an academic setting. In 1968, Ignarro left the NIH to work for Geigy Pharmaceuticals. With this company, Ignarro helped develop new drugs and was able to continue research into new areas of pharmacology including
cyclic GMP Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in ...
. After Geigy merged with Ciba Pharmaceuticals, Ignarro decided to move back to the world of academia, this time as a professor. In 1973, Ignarro accepted the position of assistant professor of pharmacology at
Tulane University Tulane University, officially the Tulane University of Louisiana, is a private research university in New Orleans, Louisiana. Founded as the Medical College of Louisiana in 1834 by seven young medical doctors, it turned into a comprehensive pub ...
School of Medicine in
New Orleans, LA New Orleans ( , ,New Orleans
Ferid Murad, who demonstrated that nitric oxide elevates cyclic GMP levels. Ignarro then speculated that nitric oxide could be the key to relaxing vascular smooth muscles. In turn, this led to his extensive research on the subject. Ignarro's research demonstrated that nitric oxide serves the functions of vasorelaxant and inhibitor of platelet aggregation, with both effects mediated by cyclic GMP. Ignarro continued his research at Tulane. In 1984 he realized that the properties of nitric oxide were the same as those seen in the endothelium derived relaxing factor ( EDRF) previously identified by Robert Furchgott 3 years earlier. The exact nature of the EDRF was up to this point unknown. Furchgott and Ignarro came to similar conclusions about nitric oxide as the EDRF around the same time, and both presented evidence at conferences during 1986 demonstrating nitric oxide's role as EDRF. During the decades since Ignarro and Furchgott's initial research, thousands of studies have been published about the effects of nitric oxide as the endothelium derived relaxing factor. This has led to the development of erectile dysfunction drugs such as
Viagra Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is effective for treating sexual dysfunction in women. It is taken by ...
and nutritional supplements designed for cardiovascular health and athletic performance. In 1985, Ignarro moved from New Orleans to Los Angeles where he accepted a position at the
UCLA The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California ...
School of Medicine and continues to research and teach.


Herbalife relationship

Ignarro has worked as a consultant for
Herbalife Herbalife Nutrition Ltd., also called Herbalife International, Inc. (with a U.S. subsidiary called Herbalife International of America) or simply Herbalife, is a global multi-level marketing (MLM) corporation that develops and sells dietary su ...
since 2003 and later became a member of the company's Scientific Advisory Board. He has collaborated in developing nutritional supplements for cardiovascular health and athletic performance. Ignarro first worked with
Herbalife Herbalife Nutrition Ltd., also called Herbalife International, Inc. (with a U.S. subsidiary called Herbalife International of America) or simply Herbalife, is a global multi-level marketing (MLM) corporation that develops and sells dietary su ...
to develop Niteworks, a dietary supplement designed to boost the body's own production of nitric oxide. Ignarro endorsed this product in exchange for a royalty agreement reported to have earned his consulting firm over $1 million in the first 12 months. Ignarro has continued to work with Herbalife to develop additional supplements focusing on nutrients such as
Omega-3 fatty acid Omega−3 fatty acids, also called Omega-3 oils, ω−3 fatty acids or ''n''−3 fatty acids, are polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond, three atoms away from the terminal methyl group in their chem ...
and CoQ10. As of 2012, Herbalife has made payments to Ignarro and his affiliated consulting firm of over $15 million. Ignarro appears in videos promoting Niteworks and other Herbalife products, and is a frequent speaker at Herbalife events. Since partnering with Herbalife, Ignarro has spoken to more than 5,000,000 people worldwide about nitric oxide and cardiovascular health.


Famous quotes

While testifying before Congress in 2000, Ignarro remarked: "Only in America could the son of an uneducated carpenter receive the Nobel Prize in Medicine".


Awards and recognitions

*Pharmaceutical Manufacturers Association Foundation Research Award. 1973 *Merck Research Award. 1974 *Edward G Schlieder Foundation Award. 1973–1976 *U.S.P.H.S. Career Development Award. 1975 – 1980 *Arthritis Foundation Research Award. 1975 – 1977 *First recipient of the George Clark Memorial Arthritis Fund. 1975 *First recipient of the James Woodrow Waggoner Arthritis Fund. 1976 *Lilly Research Award. 1978 *Tulane Medical School – Outstanding Teacher Award. 1983 *UCLA School of Medicine – Outstanding Teacher Award. 1986 *AMSA Golden Apple Award (for teaching) – UCLA School of Medicine. 1987, 1988, 1989, 1990, 1991, 1992, 1993, 1994, 1995, 1996, 1997, 1999 *
Alpha Omega Alpha Alpha Omega Alpha Honor Medical Society () is an honor society in the field of medicine. Alpha Omega Alpha currently has active Chapters in 132 LCME- accredited medical schools in the United States and Lebanon. It annually elects over 4,000 new ...
– Honorary Member. 1990 *UCLA School of Medicine Award for Excellence in Education. 1993 *Roussel Uclaf Prize for Cell Communication and Signaling. Shared with Dr. Salvador Moncada and Dr. Robert Furchgott. 1994 *Wellcome Visiting Professor – Marshall University School of Medicine. 1995 *CIBA Award for Hypertension Research for Discovery of the Roles of Nitric Oxide and Cyclic GMP in Vascular Function. Shared with Dr. Salvador Moncada. 1995 *Basic Research Prize of the American Heart Association in recognition of outstanding contributions to the advancement of cardiovascular science. 1998 *Nobel Prize in Physiology or Medicine for "nitric oxide as a signaling molecule in the cardiovascular system". Shared with Robert Furchgott and Ferid Murad. 1998 *
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...
. 1999 *
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...
. 1999 *
Institute of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Eng ...
. 2011 *
American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...
. 2007 *Canadian Medal of Merit. 2008 *American Heart Association Distinguished Scientist. 2008 *Honorary doctorates from the Universities of Madrid, Lund, Gent, North Carolina; Naples Federico II *Golden Plate Award of the
American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...
. 2014


Society memberships

*
American Society for Pharmacology and Experimental Therapeutics The American Society for Pharmacology and Experimental Therapeutics (ASPET) is a scientific society founded in late 1908 by John Jacob Abel of Johns Hopkins University (also the founder of the American Society for Biochemistry and Molecular Bio ...
* American Society for Biochemistry and Molecular Biology * American Physiological Society *
American Society for Cell Biology The American Society for Cell Biology (ASCB) is a professional society that was founded in 1960.American Rheumatism Association American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, pe ...
*
American Society of Hematology The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes th ...
*
Society for Experimental Biology and Medicine The Society for Experimental Biology and Medicine (abbreviated SEBM) is a nonprofit scientific society dedicated to promoting research in the biomedical sciences. Founding The SEBM was founded in 1903, after Samuel J. Meltzer proposed founding a ...
*
American Heart Association The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and deat ...
* Italy-USA Foundation


Book publications

* ''NO More Heart Disease: How Nitric Oxide Can Prevent – Even Reverse – Heart Disease and Strokes.'' New York: St. Martin's Press (2005). . * ''Nitric Oxide: Biology and Pathobiology.'' Academic Press (2009). . * ''Health Is Wealth: 10 Power Nutrients That Increase Your Odds Of Living To 100.'' Health Value Publications (2009). . * ''Health Is Wealth: Performance Nutrition.'' Health Value Publications (2011). . * ''Survival of the Firmest: UCLA Doctors Describe Ten Steps to Better Erections, a Longer Life and Reversing Erectile Dysfunction (ED).'' CreateSpace (2011). . * ''Dr. NO: The Discovery That Led to a Nobel Prize and Viagra.''Vertel Publishing (2022). .


Important publications

*1979 CA Gruetter, BK Barry, DB McNamara, DY Gruetter, PJ Kadowitz and LJ Ignarro. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J. Cyclic Nucl. Res. 5: 211–224. *1980 LJ Ignarro and CA Gruetter. Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: Possible involvement of S-nitrosothiols. Biochim. Biophys. Acta 631: 221–231. *1981 BT Mellion, LJ Ignarro, EH Ohlstein, EG Pontecorvo, AL Hyman and PJ Kadowitz. Evidence for the inhibitory role of guanosine 3',5'-monophosphate in ADP-induced human platelet aggregation. Blood 57: 946–955. *1981 LJ Ignarro, H Lippton, JC Edwards, WH Baricos, AL Hyman, PJ Kadowitz and CA Gruetter. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of Snitrosothiols as active intermediates. J. Pharmacol. Exp. Ther. 218: 739–749. *1982 MS Wolin, KS Wood and LJ Ignarro. Guanylate cyclase from bovine lung: a kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme and nitrosyl-heme. J. Biol. Chem. 257: 13312-13320. *1984 LJ Ignarro, B Ballot and KS Wood. Regulation of guanylate cyclase activity by porphyrins and metalloporphyrins. J. Biol. Chem. 259: 6201–6207. *1986 LJ Ignarro, RG Harbison, KS Wood and PJ Kadowitz. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J. Pharmacol. Exp. Ther. 237: 893–900. *1987 LJ Ignarro, RE Byrns, GM Buga and KS Wood. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacological and chemical properties that are identical to those for nitric oxide radical. Circ. Res. 61: 866–879. *1987 LJ Ignarro, GM Buga, KS Wood, RE Byrns and G Chaudhuri. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84: 9265–9269. *1990 LJ Ignarro, PA Bush, GM Buga, KS Wood, JM Fukuto and J Rajfer. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun. 170: 843–850. *1992 J Rajfer, WJ Aronson, PA Bush, FJ Dorey and LJ Ignarro. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med. 326: 90–94. *1994 JM Griscavage, JM Fukuto, Y Komori and LJ Ignarro. Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group: role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide. J. Biol. Chem. 269: 21644-21649. *1994 AJ Hobbs, JM Fukuto and LJ Ignarro. Formation of free nitric oxide from Larginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase. Proc. Natl. Acad. Sci. USA 91: 10992-10996. *1996 JM Griscavage, S Wilk and LJ Ignarro. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of nuclear factor-kappa B. Proc. Natl. Acad. Sci. USA 93:3308–3312. *1999 HC Champion, TJ Bivalacqua, AL Hyman, LJ Ignarro, WJG Hellstrom and PJ Kadowitz. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc. Natl. Acad. Sci. USA 96:11648-11652. *2001 LJ Ignarro, GM Buga, LH Wei, PM Bauer, G Wu and P del Soldato. Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA 98: 4202–4208. *2001 PM Bauer, GM Buga, JM Fukuto, AE Pegg and LJ Ignarro. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J. Biol. Chem. 276: 34458-34464. *2001 PM Bauer, GM Buga and LJ Ignarro. Role of p42/p44 mitogen-activated protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide. Proc. Natl. Acad. Sci. USA 98: 12802-12807. *2003 F de Nigris, LO Lerman, SW Ignarro, G Sica, A Lerman, W Palinski, LJ Ignarro and C Napoli. Beneficial effects of antioxidants and L-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress. Proc. Natl. Acad. Sci. USA 100:1420–1425. *2003 D Sumi and LJ Ignarro. Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression. Proc. Natl. Acad. Sci. USA 100:14451-14456. *2004 T Hayashi, D Sumi, PA Juliet, H Matsui-Hirai, Y Asai-Tanaka, H Kano, A Fukatsu, T Tsunekawa, A Miyazaki, A Iguchi and LJ Ignarro. Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits. Cardiovasc. Res. 61:339–351. *2004 C Napoli, SW Ignarro, F de Nigris, LO Lerman, L Rossi, C Guarino, G Mansueto, F Di Tuoro, O Pignalosa, G De Rosa, V Sica and LJ Ignarro. Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proc. Natl. Acad. Sci. USA 101:8797–8802. *2005 HJ Garban, D Marquez-Garban, R Pietras and LJ Ignarro. Rapid nitric oxidemediated S-nitrosylation of estrogen receptor: Regulation of estrogen-dependent gene transcription. Proc. Natl. Acad. Sci. USA 102:2632–2636.


See also

*
Arginine Arginine is the amino acid with the formula (H2N)(HN)CN(H)(CH2)3CH(NH2)CO2H. The molecule features a guanidino group appended to a standard amino acid framework. At physiological pH, the carboxylic acid is deprotonated (−CO2−) and both the am ...
*
Nitric Oxide Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula . It is one of the principal oxides of nitrogen. Nitric oxide is a free radical: it has an unpaired electron, which is sometimes denoted by a dot in its ...
*
Pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...
*
Pharmacy Pharmacy is the science and practice of discovering, producing, preparing, dispensing, reviewing and monitoring medications, aiming to ensure the safe, effective, and affordable use of medication, medicines. It is a miscellaneous science as it ...


References


External links


Louis Ignarro's Official Homepage
*
Louis Ignarro bio
Herbalife.com *UCL

{{DEFAULTSORT:Ignarro, Louis J. 1941 births Living people American Nobel laureates Nobel laureates in Physiology or Medicine American pharmacologists David Geffen School of Medicine at UCLA faculty University of Minnesota College of Pharmacy alumni Columbia University College of Pharmacy alumni Tulane University faculty Members of the United States National Academy of Sciences King Saud University faculty American people of Italian descent Long Beach High School (New York) alumni People from Long Beach, New York Members of the National Academy of Medicine