A research group led by

Raphael Mechoulam Raphael Mechoulam (; 5 November 1930 – 9 March 2023) was a Bulgarian-born Israeli organic chemist and a professor in the Department of Natural Materials at the School of Pharmacy in the Faculty of Medicine of the Hebrew University of Jerusalem. ...

Hebrew University The Hebrew University of Jerusalem (HUJI; ) is an Israeli public research university based in Jerusalem. Co-founded by Albert Einstein and Chaim Weizmann in July 1918, the public university officially opened on 1 April 1925. It is the second-ol ...

has synthesized many cannabinoids. Some of those are: *

HU-210 HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1''R'',5''S'')- myrtenol by a group led by Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an ...

— a high affinity CB₁ agonist (''K''_i = 0.23 nM) *

HU-211 Dexanabinol (HU-211 or ETS2101) is a synthetic cannabinoid derivative in development by e-Therapeutics plc. It is the "unnatural" enantiomer of the potent cannabinoid agonist HU-210. Unlike other cannabinoid derivatives, HU-211 does not act as a ...

— the (+)-enantiomer of

with dramatically reduced CB₁ affinity * HU-239 — also known as

ajulemic acid Lenabasum (also known as ajulemic acid, 1',1'-dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid, DMH-D8-THC-11-OIC, AB-III-56, HU-239, IP-751, CPL 7075, CT-3, JBT-101, Anabasum, and Resunab) is a synthetic cannabinoid that shows anti-fibro ...

HU-243 HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly used reference agonist HU-210. It is a methylene homologue of canbisol. It is a potent agonist at both the CB1 and C ...

HU-308 Onternabez (also known as HU-308, HU308, PPP-003, and ARDS-003) is a synthetic cannabinoid that acts as a potent cannabinoid agonist. It is highly selective for the cannabinoid-2 receptor (CB2 receptor) subtype, with a selectivity more than 5,00 ...

HU-320 HU-320 (7-nor-7-carboxy-CBD-1,1-DMH) is a drug related to cannabidiol, which has strong antiinflammatory and immunosuppressive properties while demonstrating no psychoactive effects. See also * 7-Hydroxycannabidiol * Ajulemic acid * HU-210 * HU- ...

HU-331 HU-331 is a quinone anticarcinogenic drug synthesized from cannabidiol, a cannabinoid in the ''Cannabis sativa'' plant. It showed a great efficacy against oncogenic human cells. HU-331 does not cause arrest in cell cycle, cell apoptosis or casp ...

HU-336 HU-336 is a strongly antiangiogenic compound, significantly inhibiting angiogenesis at concentrations as low as 300 nM. It inhibits angiogenesis by directly inducing apoptosis of vascular endothelial cells without changing the expression of ...

HU-345 HU-345 (cannabinol quinone) is a drug that is able to angiogenesis inhibitor, inhibit aortic ring angiogenesis more potently than its parent compound cannabinol (CBN). It exhibits no psychoactive effects on the body. HU-345 can be derived thr ...