Laughter-induced syncope is an unusual but recognized form of situational syncope (fainting) likely to have a similar pathophysiological origin to tussive syncope. One reported case occurred while a patient was watching the television show ''

Seinfeld ''Seinfeld'' ( ) is an American television sitcom created by Larry David and Jerry Seinfeld that originally aired on NBC from July 5, 1989, to May 14, 1998, with a total of nine seasons consisting of List of Seinfeld episodes, 180 episodes. It ...

'', and was given the name Seinfeld syncope. There are few case reports of this syndrome in the literature. Patients, as in this case, might present initially to the

emergency department An emergency department (ED), also known as an accident and emergency department (A&E), emergency room (ER), emergency ward (EW) or casualty department, is a medical treatment facility specializing in emergency medicine, the Acute (medicine), ...

, and

laughter Laughter is a pleasant physical reaction and emotion consisting usually of rhythmical, usually audible contractions of the diaphragm and other parts of the respiratory system. It is a response to certain external or internal stimuli. Laug ...

should be considered among the numerous differentials for syncope. Laughter-induced syncope should not be confused with

cataplexy Cataplexy is a sudden and transient episode of muscle weakness accompanied by full conscious awareness, typically triggered by emotions such as laughing, crying, or terror. Cataplexy is the first symptom to appear in about 10% of cases of narcol ...

, a sudden loss of muscle tone triggered by strong emotions, particularly laughter. Unlike syncope, there is no loss of consciousness in cataplexy, which affects 65-75% of patients with

narcolepsy Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. The symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-r ...

. To date there have been few cases of laughter-induced syncope documented in medical literature.

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