The K
i Database (or K
i DB) is a
public domain database of published
binding affinities
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a m ...
(''K''
i) of
drugs
A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhalat ...
and
chemical compounds for
receptors,
neurotransmitter transporters,
ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of io ...
s, and
enzymes
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
. The resource is maintained by the
University of North Carolina at Chapel Hill and is funded by the
NIMH Psychoactive Drug Screening Program and by a gift from the
Heffter Research Institute. , the database had data for 7 449 compounds at 738 different receptors and, , 6 7696 ''K''
i values.
The Ki database has data useful for both chemical biology and
chemogenetics.
External links
DescriptionSearch formBindingDB.org - A similar publicly available database
Biological databases
Chemical databases
Public domain databases
{{pharmacology-stub