Karl Sax
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Karl Sax (November 2, 1892 – October 8, 1973) was an American botanist and geneticist, noted for his research in
cytogenetics Cytogenetics is essentially a branch of genetics, but is also a part of cell biology/cytology (a subdivision of human anatomy), that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis an ...
and the effect of radiation on
chromosome A chromosome is a package of DNA containing part or all of the genetic material of an organism. In most chromosomes, the very long thin DNA fibers are coated with nucleosome-forming packaging proteins; in eukaryotic cells, the most import ...
s.


Early life and education

Sax was born in
Spokane, Washington Spokane ( ) is the most populous city in eastern Washington and the county seat of Spokane County, Washington, United States. It lies along the Spokane River, adjacent to the Selkirk Mountains, and west of the Rocky Mountain foothills, south o ...
, in 1892. His parents were pioneer farmers and active in civic affairs; his father was the mayor of Colville, Washington. Sax's early education was in the Colville schools, and in 1912 he continued his studies at Washington State College. He majored in
agriculture Agriculture encompasses crop and livestock production, aquaculture, and forestry for food and non-food products. Agriculture was a key factor in the rise of sedentary human civilization, whereby farming of domesticated species created ...
, and his subsequent decision to undertake graduate work was influenced by the botanist and plant breeder Edward Gaines. In college, he met and married Hally Jolivette, his
cytology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...
teacher, and they later had three sons. Following his graduation, Hally accepted a position at
Wellesley College Wellesley College is a Private university, private Women's colleges in the United States, historically women's Liberal arts colleges in the United States, liberal arts college in Wellesley, Massachusetts, United States. Founded in 1870 by Henr ...
in
Wellesley, Massachusetts Wellesley () is a town in Norfolk County, Massachusetts, United States. Wellesley is part of the Greater Boston metropolitan area. The population was 29,550 at the time of the 2020 census. Wellesley College, Babson College, and a campus of M ...
, and they moved to the East Coast in 1916. Sax enrolled in the doctoral program at the Bussey Institution Graduate School of Applied Biology at
Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...
in
Cambridge, Massachusetts Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston. The city's population as of the 2020 United States census, ...
, and completed his MA in 1917. He went on to do his doctoral work at
Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...
, receiving his D.Sc. in 1922. He served as a private in the
US Army The United States Army (USA) is the primary land service branch of the United States Department of Defense. It is designated as the Army of the United States in the United States Constitution.Article II, section 2, clause 1 of the United Stat ...
from 1917 to 1918 in
World War I World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting to ...
.


Scientific career

In 1918, Sax took a job as an instructor in the Department of Genetics at the
University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after t ...
, where he worked with E. B. Babcock on the genetics of the genus '' Crepis''. In 1920 he took an appointment at the Riverbank Laboratories in
Geneva, Illinois Geneva is a city in and the county seat of Kane County, Illinois, United States. It is located in the far western side of the Chicago suburbs. Per the 2020 United States Census, 2020 census, the population was 21,393. Geneva is part of a Tri-Ci ...
, working on wheat genetics, but he moved on from that job soon after when he took a position at the Maine
Agricultural Experiment Station An agricultural experiment station (AES) or agricultural research station (ARS) is a scientific research center that investigates difficulties and potential improvements to food production and agribusiness. Experiment station scientists work with ...
in
Orono, Maine Orono ( ) is a New England town, town in Penobscot County, Maine, United States. Located on the Penobscot River, Penobscot and Stillwater River (Maine), Stillwater rivers, it was first settled by Province of Maine, American colonists in 1774. ...
. In 1928, he left Orono to take a teaching position in Harvard's genetics department at the Bussey Institution. However, the department was dissolved before his arrival, and he transferred to the cytology department at the university's Biological Laboratories in Cambridge, Massachusetts.


Contribution to radiation cytology

In 1938 Sax published a paper on chromosome aberrations, which demonstrated that radiation could induce major genetic changes by affecting
chromosomal translocations In genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes "balanced" and "unbalanced" translocation, with three main types: "reciprocal", "nonreciprocal" and "Robertsonian" transloc ...
, a
chromosome abnormality A chromosomal abnormality, chromosomal anomaly, chromosomal aberration, chromosomal mutation, or chromosomal disorder is a missing, extra, or irregular portion of chromosomal DNA. These can occur in the form of numerical abnormalities, where the ...
. The paper is thought to mark the beginning of the field of radiation cytology, and led him to be called the "father of radiation cytology."


Plant breeding

Sax bred new varieties of ornamental trees and shrubs including ''
Malus ''Malus'' ( or ) is a genus of about 32–57 species of small deciduous trees or shrubs in the family Rosaceae, including the domesticated orchard apple, crab apples (sometimes known in North America as crabapples) and wild apples. The genus i ...
'' species (both
apples An apple is a round, edible fruit produced by an apple tree (''Malus'' spp.). Fruit trees of the orchard or domestic apple (''Malus domestica''), the most widely grown in the genus, are agriculture, cultivated worldwide. The tree originated ...
and
crabapples ''Malus'' ( or ) is a genus of about 32–57 species of small deciduous trees or shrubs in the family Rosaceae, including the domesticated orchard apple, crab apples (sometimes known in North America as crabapples) and wild apples. The genus i ...
),
magnolia ''Magnolia'' is a large genus of about 210 to 340The number of species in the genus ''Magnolia'' depends on the taxonomic view that one takes up. Recent molecular and morphological research shows that former genera ''Talauma'', ''Dugandiodendr ...
s,
forsythia ''Forsythia'' , is a genus of flowering plants in the olive family Oleaceae. There are about 11 species, mostly native to Eastern Asia, but one native to Southeastern Europe. ''Forsythia'' – also one of the plant's common names – is named ...
s, and
cherries A cherry is the fruit of many plants of the genus ''Prunus'', and is a fleshy drupe (stone fruit). Commercial cherries are obtained from cultivars of several species, such as the sweet ''Prunus avium'' and the sour ''Prunus cerasus''. The name ...
. He hybridized two Japanese cherries, '' Prunus subhirtella'' and ''Prunus'' x ''yedoensis,'' then back-crossed the resulting hybrid with ''P. subhirtella,'' and named his cross ''Prunus Hally Jolivette'', in honor of his wife. A cultivar of ''
Forsythia ''Forsythia'' , is a genus of flowering plants in the olive family Oleaceae. There are about 11 species, mostly native to Eastern Asia, but one native to Southeastern Europe. ''Forsythia'' – also one of the plant's common names – is named ...
'' bred by Sax was named 'Karl Sax' by a nurseryman. In 1946, he was appointed acting director of Harvard's
Arnold Arboretum The Arnold Arboretum is a botanical research institution and free public park affiliated with Harvard University and located in the Jamaica Plain and Roslindale, Massachusetts, Roslindale neighborhoods of Boston. Established in 1872, it is the ...
, becoming the director in 1947, a post he held until 1954.


Demography

Sax was also interested in human demography. In 1955, he wrote ''Standing Room Only: The Challenge to Overpopulation'', on the consequences of uncontrolled human population growth. Sax became associated with
Planned Parenthood The Planned Parenthood Federation of America, Inc. (PPFA), or simply Planned Parenthood, is an American nonprofit organization
and was a member of the Population Association of America.


Honors

Sax was an elected member of the
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...
and the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...
. In 1966, he and Hally were co-recipients of the Mary Soper Pope Memorial Award in botany."Cranbrook Institute of Science Director's Papers"
Cranbrook website. Retrieved Dec. 27, 2016.
In 1959, he retired and moved to
Media, Pennsylvania Media is a borough (Pennsylvania), borough in and the county seat of Delaware County, Pennsylvania, United States. It is located about west of Philadelphia. It is part of the Delaware Valley, also known as the Philadelphia metropolitan area. ...
, where he continued his work on plant breeding. Karl Sax died on October 8, 1973, aged 80, at Bryn Mawr Hospital,
Bryn Mawr, Pennsylvania Bryn Mawr (, from Welsh language, Welsh for 'big hill') is a census-designated place (CDP) located in Pennsylvania, United States. It is located just west of Philadelphia along Lancaster Avenue, also known as U.S. Route 30 in Pennsylvania, U.S. ...
, U.S.


References


"Dr. Karl Sax Dies"
''New York Times'', Oct. 10, 1973. *Smocovitis, V. B. Sax, Karl. 'American National Biography Online''. Oxford University Press *Swanson, C. P. 1988. Cytogenetics and Karl Sax. ''Genetics'' 119:5–7


External links



written by Carl P. Swanson and Norman H. Giles for the U.S.
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...
, a superb source of information about Sax and his work {{DEFAULTSORT:Sax, Karl 1892 births 1973 deaths 20th-century American botanists Arnold Arboretum American geneticists Washington State University alumni Bussey Institution alumni University of California, Berkeley faculty Members of the United States National Academy of Sciences United States Army soldiers United States Army personnel of World War I People from Colville, Washington