Jacques Dubochet

Jacques Dubochet (born 8 June 1942) is a retired Swiss biophysicist. He is a former researcher at the European Molecular Biology Laboratory in Heidelberg, Germany, and an honorary professor of biophysics at the University of Lausanne in Switzerland.

In 2017, he received the Nobel Prize in Chemistry together with Joachim Frank and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution". He received the Royal Photographic Society Progress Medal, alongside his colleagues Professor Joachim Frank and Dr Richard Henderson, in 2018 for 'an important advance in the scientific or technological development of photography or imaging in the widest sense'.

Career

Dubochet started to study physics at the ''École polytechnique de l' Université de Lausanne'' (now École polytechnique fédérale de Lausanne) in 1962 and obtained his degree in physical engineering in 1967. He obtained a Certificate of Molecular Biology at University of Geneva in 1969 and then began to study electron microscopy of DNA. In 1973, he completed his thesis in biophysics at University of Geneva and University of Basel.

From 1978 to 1987, Dubochet was group leader at the European Molecular Biology Laboratory in Heidelberg, then part of West Germany. From 1987 to 2007, he was professor at the University of Lausanne. In 2007, at 65 years old, he retired and became an honorary professor at the University of Lausanne.

During his career, Dubochet developed technologies in cryo-electron microscopy, cryo-electron tomography and cryo-electron microscopy of vitreous sections. These technologies are used to image individual biological structures such as protein complexes or virus particles. At Lausanne he took part in initiatives to make scientists more aware of social issues.

In 2014, Dubochet received EMBL's Lennart Philipson Award. Describing his career in 2015, Professor Gareth Griffiths, his colleague at EMBL explained: "Jacques had a vision. He found a way of freezing thin films of water so fast that crystals had no time to form hat could damage samples ..over time the technique has become increasingly important to life science research, and it is clear today it is Nobel Prize-worthy."

When asked by his university how he would like his Nobel Prize to be recognised by the institution he asked for a parking space for his bicycle which was duly given. He had cycled to his lab almost every day for 30 years.

At the end of November 2021, the Dubochet Center for Imaging (DCI), which bears his name, was launched by the Swiss Federal Institute of Technology, the University of Lausanne and the University of Geneva. Just a few weeks later, the DCI was able to make a significant contribution to deciphering the Omicron variant of the COVID 19 virus.

Personal life

Dubochet is married with two children. He has dyslexia.

In the 1970s, for the second meeting with his future wife, they went to protest against the Kaiseraugst nuclear power plant construction project. Muriel Raemy, "J'ai toujours voulu comprendre le monde", ''Moneta'', journal of the Alternative Bank Switzerland, number 2 of year 2018, pages 21-22.

Dubochet is a member of the Social Democratic Party of Switzerland, and a member of the municipal parliament of Morges, where he holds a seat on the supervisory committee.

Bibliography

* Jacques Dubochet, ''Parcours'', Éditions Rosso, 2018, 216 pages ().

Notes and references

External links

Official page
*
Blog
* including the Nobel Lecture on 8 December 2017 ''Early cryo-electron microscopy''

{{DEFAULTSORT:Dubochet, Jacques
1942 births
20th-century biologists
20th-century Swiss physicists
21st-century biologists
21st-century Swiss physicists
École Polytechnique Fédérale de Lausanne alumni
Living people
Nobel laureates in Chemistry
People with dyslexia
People from Aigle
Swiss biophysicists
Swiss Nobel laureates
University of Basel alumni
University of Geneva alumni
University of Lausanne faculty
Social Democratic Party of Switzerland politicians
Scientists with disabilities