Jason S. Lewis is a British radiochemist whose work relates to oncologic therapy and

diagnosis Diagnosis (: diagnoses) is the identification of the nature and cause of a certain phenomenon. Diagnosis is used in a lot of different academic discipline, disciplines, with variations in the use of logic, analytics, and experience, to determine " ...

. His research focus is a molecular imaging-based program focused on

radiopharmaceutical Radiopharmaceuticals, or medicinal radiocompounds, are a group of pharmaceutical drugs containing radioactive isotopes. Radiopharmaceuticals can be used as diagnostic and therapeutic agents. Radiopharmaceuticals emit radiation themselves, which ...

development as well as the study of multimodality (

PET A pet, or companion animal, is an animal kept primarily for a person's company or entertainment rather than as a working animal, livestock, or a laboratory animal. Popular pets are often considered to have attractive/ cute appearances, inte ...

, CT &

MRI Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and rad ...

) small- and

biomolecule A biomolecule or biological molecule is loosely defined as a molecule produced by a living organism and essential to one or more typically biological processes. Biomolecules include large macromolecules such as proteins, carbohydrates, lipids ...

-based agents and their clinical translation. He has worked on the development of small

molecule A molecule is a group of two or more atoms that are held together by Force, attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemi ...

s as well as radiolabeled peptides and antibodies probing the overexpression of receptors and

antigen In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...

s on

tumors A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...

Education

Jason S. Lewis was born and raised in Horndean, Hampshire, England. Lewis received his Bachelor of Science in chemistry, B.Sc. from the

University of Essex The University of Essex is a public university, public research university in Essex, England. Established by royal charter in 1965, it is one of the original plate glass university, plate glass universities. The university comprises three camp ...

in 1992. He received his Master of Science in chemistry from the University of Essex in 1993. In 1996, he received his

Doctor of Philosophy A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of Postgraduate education, graduate study and original resear ...

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

at the

University of Kent The University of Kent (formerly the University of Kent at Canterbury, abbreviated as UKC) is a Collegiate university, collegiate public university, public research university based in Kent, United Kingdom. The university was granted its roya ...

Career

Lewis taught

Radiology Radiology ( ) is the medical specialty that uses medical imaging to diagnose diseases and guide treatment within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiation), but tod ...

at the

Washington University School of Medicine Washington University School of Medicine (WashU Medicine) is the medical school of Washington University in St. Louis, located in the Central West End neighborhood of St. Louis, Missouri. Founded in 1891, the School of Medicine shares a ca ...

Mallinckrodt Institute of Radiology The Mallinckrodt Institute of Radiology (MIR), established 1931, is an academic radiology center associated with the Washington University School of Medicine, located within the Washington University Medical Center in St. Louis, Missouri. In add ...

from 2000 to 2008. He is the Emily Tow Jackson Chair in Oncology, the Vice Chairman for Research (Radiology) and Chief Attending of the Radiochemistry and Imaging Sciences Service at

Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in Manhattan in New York City. MSKCC is one of 72 National Cancer Institute– designated Comprehensive Cancer Centers. Its main campus is ...

. He also heads a laboratory in the Sloan Kettering Institute's Molecular Pharmacology Program and is a professor at the Gerstner Sloan Kettering Graduate School of Biomedical Sciences. Lewis holds joint appointments in the Departments of Radiology and the Department of Pharmacology at

Weill Cornell Medical School Weill Cornell Medicine (; officially Joan and Sanford I. Weill Medical College of Cornell University), originally Cornell University Medical College, is the medical school of Cornell University, located on the Upper East Side of Manhattan in Ne ...

, NY.

Research focus

Lewis is a proponent of development imaging tools for use in personalized medicine. Lewis designs and develops radiochemical probes for use in

nuclear medicine Nuclear medicine (nuclear radiology, nucleology), is a medical specialty involving the application of radioactivity, radioactive substances in the diagnosis and treatment of disease. Nuclear imaging is, in a sense, ''radiology done inside out'', ...

as well as multi-modality molecular imaging. The use of these probes span from oncological metabolic detection to understanding the biological processes of

cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...

and pharmacological modification. These probes can be used for

biomarker In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, ...

s in clinical trials as well as used as an agent for oncological diagnostics. He has developed multiple new small molecules that target tumor metabolism, as well as radiolabeled peptides and antibodies for use in probing overexpression of receptors and antigens on tumors for research, clinical trials and in the clinic.

Recognition

*2014 Distinguished Investigator Award from the Academy of Radiology Research *Fellow, World Molecular Imaging Society (FWMIS) * 2017 Michael J. Welch Award, Society of Nuclear Medicine and Molecular Imaging (SNMMI) * 2019 Paul C. Aebersold Award, Educational and Research Fund for Nuclear Medicine and Molecular Imaging (ERF) &

Society of Nuclear Medicine and Molecular Imaging The Society of Nuclear Medicine and Molecular Imaging (SNMMI), formerly the Society of Nuclear Medicine, is a nonprofit scientific and professional organization that promotes the science, technology and practical application of nuclear medicine a ...

* 2019 Fellow,

(FSNMMI)

Editorial board memberships

* Molecular Imaging and Biology (Editor-in-Chief) * Journal of Nuclear Medicine (Associate Editor) * ACS Bioconjugate Chemistry (Editorial Advisory Board) * Nuclear Medicine and Biology (Associate Editor-in-Chief)

References

{{DEFAULTSORT:Lewis, Jason S. 1970 births Alumni of the University of Kent Alumni of the University of Essex Living people Radiochemistry Washington University School of Medicine faculty Weill Medical College of Cornell University faculty Memorial Sloan Kettering Cancer Center faculty