Jason C. Kovacic
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Jason C. Kovacic (born 1968) is an Australian-born
cardiologist Cardiology () is the study of the heart. Cardiology is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery di ...
and
physician-scientist A physician-scientist (in North American English) or clinician-scientist (in British English and Australian English) is a physician who divides their professional time between direct clinical practice with patients and scientific research. Physicia ...
; the Robert Graham Chair and Professor of
Medicine Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...
,
University of New South Wales The University of New South Wales (UNSW) is a public research university based in Sydney, New South Wales, Australia. It was established in 1949. The university comprises seven faculties, through which it offers bachelor's, master's and docto ...
; Executive Director of the
Victor Chang Cardiac Research Institute The Victor Chang Cardiac Research Institute (VCCRI) is an Australian non-profit medical research facility that is dedicated to finding cures for cardiovascular disease. With headquarters located in Darlinghurst, New South Wales, the research hu ...
in
Sydney Sydney is the capital city of the States and territories of Australia, state of New South Wales and the List of cities in Australia by population, most populous city in Australia. Located on Australia's east coast, the metropolis surrounds Syd ...
,
Australia Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller isl ...
; and Professor of Medicine (Cardiology) at the
Icahn School of Medicine at Mount Sinai The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City, New York, United States. The school is the academic teaching arm of the Mount Sina ...
,
New York New York most commonly refers to: * New York (state), a state in the northeastern United States * New York City, the most populous city in the United States, located in the state of New York New York may also refer to: Places United Kingdom * ...
.


Education

Jason Kovacic graduated with a degree in Medicine from the
University of Melbourne The University of Melbourne (colloquially known as Melbourne University) is a public university, public research university located in Melbourne, Australia. Founded in 1853, it is Australia's second oldest university and the oldest in the state ...
in 1994. While undertaking his degree, Kovacic deferred his studies to compete in the 1986
Junior World Rowing Championships The World Rowing U19 Championships, former name World Rowing Junior Championships is an international rowing regatta organized by FISA (the International Rowing Federation). A rower or coxswain shall be classified as a Junior until 31 December ...
and to take up a
Rowing Rowing is the act of propelling a human-powered watercraft using the sweeping motions of oars to displace water and generate reactional propulsion. Rowing is functionally similar to paddling, but rowing requires oars to be mechanically a ...
Scholarship at the Australian Institute of Sport (AIS) in
Canberra Canberra ( ; ) is the capital city of Australia. Founded following the Federation of Australia, federation of the colonies of Australia as the seat of government for the new nation, it is Australia's list of cities in Australia, largest in ...
. While in Canberra, Kovacic completed a
Bachelor of Medical Science A Bachelor of Medical Sciences (BMedSci, BMedSc, BSc(Med), BMSc) is an undergraduate academic degree involving study of a variety of disciplines related to human health leading to an in depth understanding of human biology and associated research s ...
degree in exercise physiology related to
blood viscosity Hemorheology, also spelled haemorheology (''haemo'' from Greek ‘αἷμα, ''haima'' 'blood'; and ''rheology'', from Greek ῥέω ''rhéō'', ' flow' and -λoγία, ''-logia'' 'study of'), or blood rheology, is the study of flow properties o ...
in elite rowers at the AIS. Afterward, he resumed his Medicine studies in Melbourne, graduating in 1994. Kovacic also rowed for state of Victoria with members of the
Oarsome Foursome The Oarsome Foursome is the nickname for an Australian men's rowing coxless four crew who competed with a clear lineage between 1990 and 2012, winning two Olympic gold medals and one silver medal, two world championships as a coxless four, and a ...
and won the 1994 Australian Men's Interstate Eight-Oared Rowing Championship - The
King's Cup King's Cup (incl. translations), may refer to: Sports Football * Copa del Rey, Spanish for "King's Cup," the main national knockout tournament in men's football * King's Cup (Bahrain), the premier national knockout football tournament * King's ...
. Kovacic undertook a residency at
Prince of Wales Hospital Prince of Wales Hospital is a regional acute government hospital located in Sha Tin, New Territories in Hong Kong, China. It is also a teaching hospital of the Faculty of Medicine of the Chinese University of Hong Kong (CUHK). Named after Ki ...
, and cardiology specialty training at
St. Vincent's Hospital, Sydney St Vincent's Hospital, Sydney is a leading tertiary referral hospital and research facility located in Darlinghurst, Sydney. Though funded and integrated into the New South Wales state public health system, it is operated by St Vincent's Healt ...
. As a cardiology trainee in early 2003, Kovacic was the doctor for
Rolling Stones The Rolling Stones are an English Rock music, rock band formed in London in 1962. Active for over six decades, they are one of the most popular, influential, and enduring bands of the Album era, rock era. In the early 1960s, the band pione ...
for some of their Licks World Tour Australian shows. He completed his cardiology specialty training and became a Fellow of the
Royal Australasian College of Physicians The Royal Australasian College of Physicians (RACP) is a not-for-profit professional organisation responsible for training and educating physicians and paediatricians across Australia and New Zealand. The RACP is responsible for training both ...
in 2003. Kovacic pursued a PhD at the
Victor Chang Cardiac Research Institute The Victor Chang Cardiac Research Institute (VCCRI) is an Australian non-profit medical research facility that is dedicated to finding cures for cardiovascular disease. With headquarters located in Darlinghurst, New South Wales, the research hu ...
focusing on the application of
cell therapy Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T- ...
to treat patients with refractory
ischemic heart disease Coronary artery disease (CAD), also called coronary heart disease (CHD), or ischemic heart disease (IHD), is a type of heart disease involving the reduction of blood flow to the cardiac muscle due to a build-up of atheromatous plaque in the ...
. In 2007 he relocated to the US's National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH) in Bethesda, Maryland where he undertook a two-year postdoctoral fellowship with the Director,
Elizabeth Nabel Elizabeth Nabel is an American cardiologist and Executive Vice President of Strategy at ModeX Therapeutics and OPKO Health. Prior to this role, she served as President of Brigham Health and its Brigham and Women's Hospital, Professor of Medicine ...
. In 2009 Kovacic moved to Mount Sinai Hospital in New York and after a further fellowship in
interventional cardiology Interventional cardiology is a branch of cardiology that deals specifically with the catheter based treatment of structural heart diseases. Andreas Gruentzig is considered the father of interventional cardiology after the development of angioplast ...
, went on to become a faculty member in 2010. Kovacic went on to become board certified in both
internal medicine Internal medicine, also known as general medicine in Commonwealth nations, is a medical specialty for medical doctors focused on the prevention, diagnosis, and treatment of diseases in adults. Its namesake stems from "treatment of diseases of ...
and
cardiology Cardiology () is the study of the heart. Cardiology is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery di ...
with the
American Board of Internal Medicine The American Board of Internal Medicine (ABIM) is a 501(c)(3) nonprofit, self-appointed physician-evaluation organization that certifies physicians practicing internal medicine and its subspecialties. The American Board of Internal Medicine is no ...
.


Career and research

As a physician-scientist, cardiologist and investigator at the
Icahn School of Medicine at Mount Sinai The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City, New York, United States. The school is the academic teaching arm of the Mount Sina ...
. Kovacic established a cardiovascular research laboratory with an interest in the cellular,
molecular A molecule is a group of two or more atoms that are held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemistry, ...
and
gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
tic mechanisms underlying
cardiovascular disease Cardiovascular disease (CVD) is any disease involving the heart or blood vessels. CVDs constitute a class of diseases that includes: coronary artery diseases (e.g. angina, heart attack), heart failure, hypertensive heart disease, rheumati ...
His lab at Mount Sinai received its first
NIH The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
grant in 2010. Kovacic's scientific achievements include successful investigator-initiated
clinical studies Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...
of cardiovascular
progenitor cell A progenitor cell is a biological cell that can differentiate into a specific cell type. Stem cells and progenitor cells have this ability in common. However, stem cells are less specified than progenitor cells. Progenitor cells can only diffe ...
therapy, molecular characterization of a novel
vascular Vascular can refer to: * blood vessels, the vascular system in animals * vascular tissue Vascular tissue is a complex transporting tissue, formed of more than one cell type, found in vascular plants. The primary components of vascular tissue ...
progenitor cell population unravelling the
pathobiology Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...
of
fibromuscular dysplasia Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disease of the blood vessels that causes abnormal growth within the wall of an artery. FMD has been found in nearly every arterial bed in the body, although the most commo ...
and
spontaneous coronary artery dissection Spontaneous coronary artery dissection (SCAD) is an uncommon but potentially lethal condition in which one of the coronary arteries that supply the heart, spontaneously develops a blood collection, or hematoma, within the artery wall due to a tea ...
, numerous basic and translational studies on the biology and manifestations of
atherosclerosis Atherosclerosis is a pattern of the disease arteriosclerosis, characterized by development of abnormalities called lesions in walls of arteries. This is a chronic inflammatory disease involving many different cell types and is driven by eleva ...
, and studies regarding the role of
endothelial The endothelium (: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the res ...
to
mesenchymal Mesenchyme () is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood, or bone. The interactions between mesenchyme and epithelium help to form nearly ever ...
transition (EndMT) in adult vascular biology and disease. Kovacic also established a
clinical practice ''Clinical Practice'' is a bimonthly peer-reviewed open access medical journal. It covers good clinical practice and health care. The journal was established in 2004 as ''Therapy'' by Future Drugs Ltd, obtaining its current name in 2012 when it wa ...
as an interventional and clinical cardiologist. From 2015 to 2020, Kovacic was the Associate Director of the Interventional
Structural Heart Disease Structural heart disease, also known as structural cardiac disease, is a collection of heart diseases that includes heart failure, coronary artery disease, hypertrophic cardiomyopathy, and congenital heart disease A congenital heart defect (CHD ...
Program at Mount Sinai Hospital. Kovacic became full Professor of Medicine (Cardiology) at Mount Sinai Hospital, and in 2019 was the Director of Cardiovascular Translational Science and Acting Director of the Cardiovascular Research Center at the
Icahn School of Medicine at Mount Sinai The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City, New York, United States. The school is the academic teaching arm of the Mount Sina ...
. In 2020 Kovacic became the Executive Director of the Victor Chang Cardiac Research Institute and the Robert Graham Chair and Professor of Cardiovascular Research at the University of New South Wales. His cardiovascular research program spans Mount Sinai and the Victor Chang Cardiac Research Institute. He also works as a cardiologist at
St. Vincent's Hospital, Sydney St Vincent's Hospital, Sydney is a leading tertiary referral hospital and research facility located in Darlinghurst, Sydney. Though funded and integrated into the New South Wales state public health system, it is operated by St Vincent's Healt ...


Awards and recognition

* 1985 – Valedictorian of
Caulfield Grammar School Caulfield Grammar School is a private, co-educational, Anglican, International Baccalaureate, day and boarding school, located in Melbourne, Victoria, Australia. Founded in 1881 as a boys' school, Caulfield Grammar began admitting girls exactly ...
, Melbourne, Australia. * 1992 – Recipient of Academic Achievement Award from
Australian Institute of Sport The Australian Institute of Sport (AIS) is a high performance sports training institution in Australia. The institute's headquarters were opened in 1981 and are situated in the northern suburb of Bruce, Canberra. The AIS is a division of the ...
. * 2005 – Australian Delegate to Lindau Nobel Prizewinners Meeting in Lake Constance, Germany. * 2009 – Recipient of FARE award from
National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
. * 2010 – Recipient of Dedication and Achievement Award, The Zena and Michael A. Weiner Cardiovascular Institute and The Marie-Josee and Henry R. Kravis Center for Cardiovascular Health,
Mount Sinai Medical Center Mount Sinai Hospital, formerly at times known as Mount Sinai Medical Center, is a 319-bed major urban hospital in Chicago, Illinois, with its main campus located adjacent to Douglass Park at 15th Street and California Avenue on the city's West Si ...
. * 2013 – Kovacic was recognized as an 'Emerging Leader' by the Society for Cardiovascular Angiography and Interventions, and the
American College of Cardiology The American College of Cardiology (ACC), based in Washington, D.C., is a nonprofit medical association established in 1949. It bestows credentials upon cardiovascular specialists who meet its qualifications. Education is a core component of the ...
. * 2015 – Named an 'Elite Reviewer' by the
Journal of the American College of Cardiology The ''Journal of the American College of Cardiology'' is a peer-reviewed medical journal covering all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the-a ...
. * 2017 – Kovacic was admitted into Mount Sinai LEAD Academy (Leadership Emerging in Academic Departments). * 2018 – Kovacic received the Cullman Family Award for Excellence in Physician Communication for ranking in the top 1% nationally in provider communication by
CMS CMS may refer to: Computing * Call management system * CMS-2, a programming language implemented for and used by the United States Navy * Code Morphing Software, a technology used by Transmeta * Collection management system for a museum coll ...
’s CG CAHPS patient experience survey and Deans Healthcare System Team Science Award for the
Icahn School of Medicine at Mount Sinai The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City, New York, United States. The school is the academic teaching arm of the Mount Sina ...
(as PI of the DEFINE-FMD study). * 2019 – Kovacic received the Founders Award from the Fibromuscular Dysplasia Society of America.


Other contributions

Kovacic has given over 60 US and other international invited presentations and served on many US
NIH The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
committees and panels. He is Section Editor of the
Journal of the American College of Cardiology The ''Journal of the American College of Cardiology'' is a peer-reviewed medical journal covering all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the-a ...
. and an Editorial Board Member at the journals
Vascular Medicine Angiology (from Greek , ''angeīon'', "vessel"; and , ''-logia'') is the medical specialty dedicated to studying the circulatory system and of the lymphatic system, i.e., arteries, veins and lymphatic vessels. In the UK, this field is more of ...
and Cardiovascular Research. He is also on the Board of Directors of the Australian Cardiovascular Alliance (ACvA)


References

{{DEFAULTSORT:Kovacic, Jason Australian cardiologists 1968 births Living people People educated at Caulfield Grammar School Fellows of the Royal Australasian College of Physicians Fellows of the American College of Cardiology University of Melbourne alumni University of New South Wales alumni