JZ-IV-10
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JZ-IV-10 is a
piperidine Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor de ...
derivative related to
cocaine Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...
which acts as a highly potent
serotonin–norepinephrine–dopamine reuptake inhibitor A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and do ...
(also called SNDRI, or triple reuptake inhibitor). The
eugeroic A eugeroic, or eugregoric, is a type of drug that increases wakefulness. The term has been used inconsistently and in multiple ways in the scientific literature, either to refer specifically to modafinil-type wakefulness-promoting agents or to ...
modafinil Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and wakefulness-promoting agent, eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, a sleep disorder characteri ...
was used as a lead to fuel this compound's discovery.


See also

*
1-Methyl-3-propyl-4-(p-chlorophenyl)piperidine 1-Methyl-3-propyl-4-(''p''-chlorophenyl)piperidine is a drug developed by a team led by Alan Kozikowski, which acts as a potent dopamine reuptake inhibitor, and was developed as a potential therapeutic agent for the treatment of cocaine addicti ...
*
JJC8-088 JJC8-088 is a dopamine reuptake inhibitor (DRI) that was chemical derivative, derived from the wakefulness-promoting agent modafinil. It has substantially higher affinity (pharmacology), affinity for the dopamine transporter (DAT) than modafinil ...
* N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate *
Nocaine (+)-CPCA (nocaine, 3α-carbomethoxy-4β-(4-chlorophenyl)-''N''-methylpiperidine aka CTDP 31,446) is a stimulant drug similar in structure to pethidine (an opioid that possesses NDRI actions) and to RTI-31, but nocaine lacks the two-carbon brid ...


References

Stimulants Carboxamides 4-Phenylpiperidines 4-Chlorophenyl compounds Serotonin–norepinephrine–dopamine reuptake inhibitors {{nervous-system-drug-stub