JWH-302 (1-pentyl-3-(3-methoxyphenylacetyl)indole) is an

analgesic An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...

chemical from the phenylacetylindole family, which acts as a

cannabinoid Cannabinoids () are several structural classes of compounds found primarily in the ''Cannabis'' plant or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoact ...

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

with moderate affinity at both the CB₁ and CB₂ receptors. It is a positional isomer of the more common drug

JWH-250 JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the Cannabinoid receptor 1, CB1 and Cannabinoid receptor 2 (macrophage), CB2 receptors, w ...

, though it is slightly less potent with a ''K''_i of 17 nM at CB₁, compared to 11 nM for JWH-250. Because of their identical

molecular weight A molecule is a group of two or more atoms that are held together by Force, attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemi ...

and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GC-MS testing. In the United States, CB₁ receptor agonists of the 3-phenylacetylindole class such as JWH-302 are

Schedule I Controlled Substance The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United State ...

References

JWH cannabinoids Phenylacetylindoles 3-Methoxyphenyl compounds CB1 receptor agonists CB2 receptor agonists {{Cannabinoid-stub