JWH-200 (WIN 55,225) is an

analgesic An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...

chemical from the aminoalkylindole family that acts as a

cannabinoid Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...

receptor agonist. Its binding affinity, ''K''_i at the CB₁ receptor is 42 nM, around the same as that of THC, but its analgesic potency ''in vivo'' was higher than that of other analogues with stronger CB₁ binding affinity ''in vitro'', around 3 times that of THC but with less sedative effect, most likely reflecting favourable

pharmacokinetic Pharmacokinetics (from Ancient Greek ''pharmakon'' "drug" and ''kinetikos'' "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered ...

characteristics. It was discovered in 1991 by

Sterling Drug Sterling Drug was an American global pharmaceutical company, also known as Sterling Winthrop, Inc. in its last years (after the merger with Winthrop-Stearns Inc. which itself resulted from the merger of ''Winthrop Chemical Company Inc.'' and '' ...

as a potential

following the earlier identification of related compounds such as pravadoline and

WIN 55,212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. WIN 55,212-2 is a potent ca ...

Legal status

Australia

JWH-200 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.

Canada

In July 2015, JWH-200 became a controlled substance in Canada.

United States

The US DEA temporarily declared JWH-200 a

schedule I controlled substance This is the list of Schedule I drugs as defined by the United States Controlled Substances Act.21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pla ...

on 1 March 2011 through 76 FR 11075, and permanently instated the same schedule on 9 July 2012 in the Section 1152 of the

Food and Drug Administration Safety and Innovation Act The Food and Drug Administration Safety and Innovation Act of 2012 (FDASIA) is a piece of American regulatory legislation signed into law on July 9, 2012. It gives the United States Food and Drug Administration (FDA) the authority to collect user ...

References

{{Hallucinogens Aminoalkylindoles Designer drugs JWH cannabinoids 4-Morpholinyl compunds Naphthoylindoles WIN compounds

Legal status

Australia

Canada

United States

See also

References