Isotta may refer to:
*the Italian form of the name
Iseult
Iseult ( ), alternatively Isolde ( ) and other spellings, is the name of several characters in the legend of Tristan and Iseult. The most prominent is Iseult the Blonde, or Iseult of Ireland, the wife of Mark of Cornwall and the lover of Trista ...
*
Isotta Nogarola (1418–1466), Italian writer and humanist
*
Isotta degli Atti (died 1474), an Italian regent
*
Isotta Brembati (died 1586), Italian poet and countess
*
Isotta Gervasi (1889–1967), Italian medical doctor
*
Isotta Brothers (19th century), Italian hoteliers
*
Paolo Isotta (1950–2021), Italian musicologist
*
Isotta Fraschini, Italian luxury car manufacturer
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