1-Aminopropan-2-ol is the organic compound with the formula . It is an alkanolamine, amino alcohol. The term ''isopropanolamine'' may also refer more generally to the additional Homologous series, homologs diisopropanolamine (DIPA) and triisopropanolamine (TIPA). 1-Aminopropan-2-ol is Chirality (chemistry), chiral. It can be prepared by the addition of aqueous ammonia to propylene oxide.

Biosynthesis

(''R'')-1-Aminopropan-2-ol is one of the components incorporated in the biosynthesis of cobalamin. The ''O''-phosphate ester is produced from threonine by the enzyme Threonine-phosphate decarboxylase.

Applications

The isopropanolamines are used as Buffer solution, buffers. They are good solubilizers of oil and fat, so they are used to neutralize fatty acids and sulfonic acid-based surfactants. Racemic 1-aminopropan-2-ol is typically used in metalworking fluid, waterborne coatings, personal care products, and in the production of titanium dioxide and polyurethanes. It is an intermediate in the synthesis of a variety of pharmaceutical drugs. (''R'')-1-aminopropan-2-ol is metabolised to aminoacetone by the enzyme (R)-aminopropanol dehydrogenase, (''R'')-aminopropanol dehydrogenase. Synthesis of Hexylcaine is one application.

References

{{DEFAULTSORT:Amino-2-propanol, 1- Amines Secondary alcohols Amino alcohols