Interferon regulatory factor 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''IRF2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the
IRF1
Interferon regulatory factor 1 is a protein that in humans is encoded by the ''IRF1'' gene.
Function
Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially desc ...
-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of
histone H4
Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryote, eukaryotic cells. Featuring a main globular domain and a long N-terminus, N-terminal tail, H4 is involved with the structure of the nucleo ...
.
See also
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IRF1
Interferon regulatory factor 1 is a protein that in humans is encoded by the ''IRF1'' gene.
Function
Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially desc ...
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Interferon regulatory factors
Interferon regulatory factors (IRF) are proteins which regulate Transcription (genetics), transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain a conserved sequence, conserved N-terminal region of ...
Interactions
IRF2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
BRD7
Bromodomain-containing protein 7 is a protein that in humans is encoded by the ''BRD7'' gene.
Interactions
BRD7 has been shown to interact with IRF2 and HNRPUL1.
Azoospermia
BRD7 protein is a transcription regulator that is normally highly e ...
,
EP300
Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the ''EP300'' gene. It functions as histone ace ...
and
PCAF
P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.
Structure
Several domains of PCAF can act independently or in unison to enable its fu ...
.
References
Further reading
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External links
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Transcription factors
{{gene-4-stub