Inflammatory fibroid polyp (IFP) is a
benign abnormal growth of tissue projecting into the
lumen of the
gastrointestinal tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organ (biology), organs of the digestive syste ...
.
Pathology
IFPs consist of spindle cells that are concentrically arranged around blood vessels and have inflammation, especially
eosinophils.
They may have
leiomyoma
A leiomyoma, also known as a fibroid, is a benign smooth muscle tumor that very rarely becomes cancer (0.1%). They can occur in any organ, but the most common forms occur in the uterus, small bowel, and the esophagus. Polycythemia may occur due to ...
/
schwannoma-like areas with nuclear palisading.
They typically stain with
CD34[ and vimentin,]differential diagnosis
In healthcare, a differential diagnosis (abbreviated DDx) is a method of analysis of a patient's history and physical examination to arrive at the correct diagnosis. It involves distinguishing a particular disease or condition from others that p ...
includes other benign, pre-malignant and malignant gastrointestinal polyps.
Image:Inflammatory_fibroid_polyp_-_high_mag.jpg , High mag.
Morphological differential diagnosis
*Inflammatory myofibroblastic tumour
Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm of the mesodermal cells that form the connective tissues which support virtually all of the organs and tissues of the body. IMT was formerly termed inflammatory pseudotumor. Currently, ...
(IMT)
See also
* Inflammatory pseudotumor According to the WHO classification, three lesional patterns can be observed
* Inflammatory myofibroblastic tumour, that can be associated with an ALK gene rearrangement
* Plasmocytic pattern (" plasma cell granuloma"), that can be linked to IgG4 ...
References
External links
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Digestive system