Imiloxan is a drug which is used in

scientific research The scientific method is an empirical method for acquiring knowledge that has been referred to while doing science since at least the 17th century. Historically, it was developed through the centuries from the ancient and medieval world. The ...

. It acts as a selective

antagonist An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain.α_2B

adrenergic receptor The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like b ...

, and has been useful for distinguishing the actions of the different α₂ adrenergic subtypes.

Synthesis

The

imidazole Imidazole (ImH) is an organic compound with the formula . It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. It can be classified as a heterocycle, specifically as a diazole. Many natural products, ...

portion of imiloxan is prepared by the reaction of an

imidate Carboximidates (or more general imidates) are organic compounds, which can be thought of as esters formed between an imidic acid () and an Alcohol (chemistry), alcohol, with the general formula . They are also known as imino ethers, since they ...

with the diethyl acetal of aminoacetaldehyde. ''N''-Alkylation of the imidazole with

ethyl iodide Ethyl iodide (also iodoethane) is a transparency and translucency, colorless flammable chemical compound. It has the chemical formula C2H5I and is prepared by heating ethanol with iodine and phosphorus.''Merck Index of Chemicals and Drugs'', 9th e ...

gives imiloxan.

References

External links

* Imidazolines Alpha blockers Benzodioxans {{antihypertensive-stub