Interferon-alpha/beta receptor beta chain is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''IFNAR2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The protein encoded by this gene is a
type I membrane protein that forms one of the two chains of a
receptor for interferons alpha and beta. Binding and activation of the receptor stimulates
Janus protein kinases, which in turn phosphorylate several proteins, including
STAT1 and
STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.
Interactions
IFNAR2 has been shown to
interact with:
*
GNB2L1,
IFNA2
Interferon alpha-2 is a protein that in humans is encoded by the ''IFNA2'' gene.
Protein family
Human interferon alpha-2 (IFNα2) is a cytokine belonging to the family of type I IFNs. IFNα2 is a protein secreted by cells infected by a virus ...
,[ and
* STAT2.]
References
Further reading
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{{Cytokine receptors