Hydrocortisone aceponate is a veterinary

corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are invo ...

that is used in form of creams for the treatment of various

dermatoses A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of this sys ...

(skin conditions). It is an

ester In chemistry, an ester is a compound derived from an acid (either organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group () of that acid is replaced by an organyl group (R). These compounds contain a distin ...

hydrocortisone Hydrocortisone is the name for the hormone cortisol when supplied as a medication. It is a corticosteroid and works as an anti-inflammatory and by immune suppression. Uses include conditions such as adrenocortical insufficiency, adrenogenit ...

(cortisol) with

acetic acid Acetic acid , systematically named ethanoic acid , is an acidic, colourless liquid and organic compound with the chemical formula (also written as , , or ). Vinegar is at least 4% acetic acid by volume, making acetic acid the main compone ...

and

propionic acid Propionic acid (, from the Greek language, Greek words πρῶτος : ''prōtos'', meaning "first", and πίων : ''píōn'', meaning "fat"; also known as propanoic acid) is a naturally occurring carboxylic acid with chemical formula . It is a ...

Medical uses

Hydrocortisone aceponate is typically used for skin conditions in veterinary practices for dogs. In this instance, it can be used on acute

otitis externa Otitis externa, also called swimmer's ear, is inflammation of the ear canal. It often presents with ear pain, swelling of the ear canal, and occasionally decreased hearing. Typically there is pain with movement of the outer ear. A high fever ...

, a bacterial infection causing inflammation of the ear canal, as well as a treatment for itchy skin caused by allergies. Additionally, hydrocortisone aceponate can be used to treat hormonal disorders and immune and allergic disorders. The main use for hydrocortisone aceponate is for atopic skin conditions and acute ear infections. It is shown to help with skin lesions and

inflammation Inflammation (from ) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin ''calor'', '' ...

that respond to corticosteroids but may have been resistant to other treatments. It has been approved for veterinary use in the

European Union The European Union (EU) is a supranational union, supranational political union, political and economic union of Member state of the European Union, member states that are Geography of the European Union, located primarily in Europe. The u ...

Adverse effects

Side effects include: * Inhibition of bone formation * Suppression of calcium absorption * Delayed wound healing * Redness on skin

Chemistry

Hydrocortisone aceponate is a steroid which takes the form of a diester. The diester increases transmission of the medicine through the skin and also increases the time that it remains in the affected area.

Society and culture

Brand names

Cortavance is the brand name for a veterinary medication used to treat inflamed, itchy skin, typically caused by allergies. Easotic is the brand name for a veterinary combination medication used to treat acute ear infections in dogs. It is composed of three active substances: hydrocortisone aceponate, miconazole nitrate and gentamicin. These are used in conjunction with hydrocortisone aceponate acts as an anti-inflammatory agent, miconazole nitrate has antifungal properties, and gentamicin is an antibiotic. The medication is used through ear drops and works to kill the foreign agent, prevent further spread, and mitigate symptoms.

References

Corticosteroids Propionate esters Acetate esters Corticosteroid esters Dog medications {{veterinary-med-stub