HIV Tat-specific factor 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''HTATSF1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.
HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.
It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as
Nanog and
KLF2
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the ''KLF2'' gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has ...
.
Interactions
HTATSF1 has been shown to
interact with
SUPT5H
Transcription elongation factor SPT5 is a protein that in humans is encoded by the ''SUPT5H'' gene.
Interactions
SUPT5H has been shown to interact with:
* CDK9,
* Cyclin-dependent kinase 7,
* HTATSF1,
* PIN1,
* POLR2A,
* PRMT1
Prote ...
and
GTF2F2.
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References
Further reading
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