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Grape therapy or grape diet, also known as ampelotherapy, is a diet that involves heavy consumption of grapes, including seeds, and parts of the vine, including leaves, that is a form of
alternative medicine Alternative medicine refers to practices that aim to achieve the healing effects of conventional medicine, but that typically lack biological plausibility, testability, repeatability, or supporting evidence of effectiveness. Such practices are ...
. The concept was developed in 19th-century Germany in
spa A spa is a location where mineral-rich spring water (sometimes seawater) is used to give medicinal baths. Spa health treatments are known as balneotherapy. The belief in the curative powers of mineral waters and hot springs goes back to pre ...
s such as Bad Duerkheim and
Merano Merano (, ; ) or Meran () is a (municipality) in South Tyrol, Northern Italy. Generally best known for its Spa town, spa resorts, it is located within a Depression (geology), basin, surrounded by mountains standing up to Height above mean sea ...
. The concept has no scientific basis and is regarded as
quackery Quackery, often synonymous with health fraud, is the promotion of fraudulent or Ignorance, ignorant medicine, medical practices. A quack is a "fraudulent or ignorant pretender to medical skill" or "a person who pretends, professionally or public ...
by scientific institutions like the
American Cancer Society The American Cancer Society (ACS) is a nationwide non-profit organization dedicated to eliminating cancer. The ACS publishes the journals ''Cancer'', '' CA: A Cancer Journal for Clinicians'' and '' Cancer Cytopathology''. History The society w ...
.


Background

An assumption of some of grape therapy is that consuming grape constituents would provide unusual therapeutic or nutritional benefits. However, consuming grapes has unknown effects against
cardiovascular disease Cardiovascular disease (CVD) is any disease involving the heart or blood vessels. CVDs constitute a class of diseases that includes: coronary artery diseases (e.g. angina, heart attack), heart failure, hypertensive heart disease, rheumati ...
s and other diseases, such as
metabolic syndrome Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein (HDL). Metabolic syndro ...
. Alternative medicine practitioners have recommended grapes and parts of the vine for treating various diseases, but there is no clinical evidence for any such effects. Grape
pomace Pomace ( ), or marc (; from French ''marc'' ), is the solid remains of grapes, olives, or other fruit after pressing (wine), pressing for juice or Vegetable oil, oil. It contains the skins, pulp, seeds, and stems of the fruit. Grape pomace has ...
contains various
micronutrient Micronutrients are essential chemicals required by organisms in small quantities to perform various biogeochemical processes and regulate physiological functions of cells and organs. By enabling these processes, micronutrients support the heal ...
s, but the resulting flour from pomace has variable nutrient contents due to processing, drying, and storage conditions. Raw grapes are mostly devoid of nutritional benefit, except for moderate amounts of
carbohydrate A carbohydrate () is a biomolecule composed of carbon (C), hydrogen (H), and oxygen (O) atoms. The typical hydrogen-to-oxygen atomic ratio is 2:1, analogous to that of water, and is represented by the empirical formula (where ''m'' and ''n'' ...
s and
vitamin K Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-translational modification, post-synthesis modification of certain proteins ...
(see grape nutrition).
Proanthocyanidin Proanthocyanidins are a class of polyphenols found in many plants, such as cranberry, blueberry, and grape seeds. Chemically, they are oligomeric flavonoids. Many are oligomers of catechin and epicatechin and their gallic acid esters. More complex ...
s,
anthocyanin Anthocyanins (), also called anthocyans, are solubility, water-soluble vacuole, vacuolar pigments that, depending on their pH, may appear red, purple, blue, or black. In 1835, the German pharmacist Ludwig Clamor Marquart named a chemical compou ...
s and
resveratrol Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol or polyphenol and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacterium, ba ...
extract An extract (essence) is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures or absolutes or dried and powdered. The aromatic principles of ma ...
ed from
grape seed A grape is a fruit, botanically a berry, of the deciduous woody vines of the flowering plant genus ''Vitis''. Grapes are a non- climacteric type of fruit, generally occurring in clusters. The cultivation of grapes began approximately 8,00 ...
s and grape skins are under basic research for their possible biological effects. Pomace also contains
organic acid An organic acid is an organic compound with acidic properties. The most common organic acids are the carboxylic acids, whose acidity is associated with their carboxyl group –COOH. Sulfonic acids, containing the group –SO2OH, are re ...
s ( tartaric, malic, citric, tannic), but there is no evidence for health effects from these phytochemicals.


History

The documentation of a grape diet was first seen in a publication by Dr. Veit Kaufmann, a family doctor in the viticultural city of Bad Duerkheim, Germany, called "Die Traubenkur in Dürkheim a.d. Haardt" (The Grape Treatment Course in Duerkheim at Haardt River) (1856). Kaufmann was well known locally, and a personal friend of
Rudolph Virchow Rudolf Ludwig Carl Virchow ( ; ; 13 October 18215 September 1902) was a German physician, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician. He is known as "the father of modern pathology" and as the founder o ...
, who underwent the treatment regularly. In the
USSR The Union of Soviet Socialist Republics. (USSR), commonly known as the Soviet Union, was a List of former transcontinental countries#Since 1700, transcontinental country that spanned much of Eurasia from 1922 until Dissolution of the Soviet ...
, the principles of a grape cure were developed in the 1920s by a group of physicians of the Semashko Institute (Yalta), headed by A.V. D'iakov. Ampelotherapy is offered in alternative medicine clinics and spas, particularly in Europe, together with
vinotherapy Vinotherapy, also written "Vinotherapie", describes a beauty therapy process where the residue of wine making (the pips and pulp) are rubbed into the skin. The pulp is claimed to have exfoliating qualities and to help reduce the signs of ageing. ...
, a cosmetic treatment that involves rubbing grapes into the skin.
Johanna Brandt Johanna Brandt (18 November 1876 in Heidelberg, South African Republic – 13 January 1964 in Newlands, Cape Town) was a South African propagandist of Afrikaner nationalism, spy during the Boer War, prophet and writer on health subjects. Biog ...
, a South African author, popularized the grape diet as a treatment for cancer from 1925. She published about twenty pamphlets on the subject of natural remedies for health problems with her book ''The Grape Cure'', which is said to have been written after Brandt had cured herself of stomach cancer by following the diet. The book was republished in 1989 as ''How to Conquer Cancer, Naturally'', including an endorsement of Brandt's work by
Benedict Lust Benedict Lust (February 3, 1872 – September 5, 1945) was a German-American who was one of the founders of naturopathic medicine in the first decades of the twentieth century. Biography Lust was born in Michelbach, Baden, Germany.Anonymous. ( ...
, who is commonly referred to as "the father of naturopathy". Although commonly used as a
dietary supplement A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill (pharmacy), pill, capsule (pharmacy), capsule, tablet (pharmacy), tablet, powder, or liquid. A supplement can provide nutrients eithe ...
and studied in human trials at an amount much higher than can be consumed from drinking red wine, there is no high-quality evidence that resveratrol provides any benefits for cardiovascular risk factors. Advocates of grape therapy argue that grape phytochemicals inhibit the development of cancer,
arthritis Arthritis is a general medical term used to describe a disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, Joint effusion, swelling, and decreased range of motion of ...
or
diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...
, but there is no scientific evidence for such effects.


Treatments

The diet proposed by Veit Kaufmann recommended the consumption of several pounds of freshly picked grapes a day, spread over 4 portions, combined with walks, sports and light healthy meals, over a course of three to six weeks in a spa, overseen by medical personnel. The diet proposed by Johanna Brandt recommended fasting for two or three days, consuming only cold water, followed by a diet of only grapes and water for one to two weeks, with seven meals a day. Fresh fruits, tomatoes, and sour milk or cottage cheese are then introduced to the diet followed by raw vegetables.


Criticisms

Available scientific evidence does not support claims that a diet of grapes is effective for treating cancer or any other disease. The Brandt diet, in particular, has been described as "quackery" by Barrett who notes that the
American Cancer Society The American Cancer Society (ACS) is a nationwide non-profit organization dedicated to eliminating cancer. The ACS publishes the journals ''Cancer'', '' CA: A Cancer Journal for Clinicians'' and '' Cancer Cytopathology''. History The society w ...
reviewed ''The Grape Cure'' in 1965, 1971, 1974, and 2000 and found no evidence of benefit against human cancer or any other disease. Grape seed extract has been identified by the U.S.
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
as a "fake cancer 'cure'".


See also

*
Urine therapy Urine therapy or urotherapy, (also urinotherapy, Shivambu, uropathy, or auto-urine therapy) in alternative medicine, and Amaroli in medieval hatha yoga, is the application of human urine for medicinal or cosmetic purposes, including urophagia, ...
*
Gerson therapy Max Gerson (October 18, 1881 – March 8, 1959) was a German-born American physician who developed the Gerson therapy, a pseudoscientific dietary-based alternative cancer treatment that he falsely claimed could cure cancer and most chronic, ...
*
List of unproven and disproven cancer treatments This is a non-exhaustive list of alternative cancer treatments, alternative treatments that have been promoted to treat or prevent cancer in humans but which lack scientific and medical evidence of effectiveness. In many cases, there is scientif ...


References

{{Authority control Alternative cancer treatments
Therapy A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis. Both words, ''treatment'' and ''therapy'', are often abbreviated tx, Tx, or Tx. As a rule, each therapy has indications a ...
Naturopathy Pseudoscience