In molecular biology, the GRIP domain is a conserved

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...

. The GRIP (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain is found in many large coiled-coil

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

s. It has been shown to be sufficient for targeting to the

Golgi Golgi may refer to: *Camillo Golgi (1843–1926), Italian physician and scientist after whom the following terms are named: **Golgi apparatus (also called the Golgi body, Golgi complex, or dictyosome), an organelle in a eukaryotic cell **Golgi tend ...

. It contains a completely conserved

tyrosine -Tyrosine or tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. The word "tyrosine" is from the Gr ...

residue.

References

{{InterPro content, IPR000237 Protein families