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Frank John Fenner (21 December 1914 – 22 November 2010) was an Australian scientist with a distinguished career in the field of
virology Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, the ...
. His two greatest achievements are cited as overseeing the eradication of
smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...
, and the attempted control of Australia's rabbit plague through the introduction of ''
Myxoma virus ''Myxoma virus'' is a poxvirus in the genus ''Leporipoxvirus''. The two broad geographic types of ''myxoma virus'' are Californian and South American. Californian ''myxoma virus'' is found on the West Coast of the United States, the Baja Penins ...
''. The
Australian Academy of Science The Australian Academy of Science was founded in 1954 by a group of distinguished Australians, including Australian Fellows of the Royal Society of London. The first president was Sir Mark Oliphant. The academy is modelled after the Royal Soc ...
awards annually the prestigious
Fenner Medal The Fenner Medal, named after the Australian virologist Frank Fenner, is awarded each year by The Australian Academy of Science for distinguished research in biology (excluding the biomedical sciences Biomedical sciences are a set of science ...
for distinguished research in biology by a scientist under 40 years of age.


Early life and education

Frank Johannes Fenner was born in
Ballarat Ballarat ( ) is a city in the Central Highlands of Victoria, Australia. At the 2021 Census, Ballarat had a population of 116,201, making it the third largest city in Victoria. Estimated resident population, 30 June 2018. Within months of Vi ...
in 1914. The family moved to
Adelaide Adelaide ( ) is the capital city of South Australia, the state's largest city and the fifth-most populous city in Australia. "Adelaide" may refer to either Greater Adelaide (including the Adelaide Hills) or the Adelaide city centre. The dem ...
,
South Australia South Australia (commonly abbreviated as SA) is a States and territories of Australia, state in the southern central part of Australia. It covers some of the most arid parts of the country. With a total land area of , it is the fourth-largest o ...
in November 1916. He attended Rose Park Primary School and Thebarton Technical School. He attended the
University of Adelaide The University of Adelaide (informally Adelaide University) is a public research university located in Adelaide, South Australia. Established in 1874, it is the third-oldest university in Australia. The university's main campus is located on N ...
, where he earned degrees in medicine and surgery in 1938. That year, uneasy about Hitler's rise, he legally changed his middle name to John.


Career

In May 1937, Fenner was a member of an Adelaide University anthropological expedition to Nepabunna Mission in the northern
Flinders Ranges The Flinders Ranges are the largest mountain range in South Australia, which starts about north of Adelaide. The ranges stretch for over from Port Pirie to Lake Callabonna. The Adnyamathanha people are the Aboriginal group who have inhabit ...
in
South Australia South Australia (commonly abbreviated as SA) is a States and territories of Australia, state in the southern central part of Australia. It covers some of the most arid parts of the country. With a total land area of , it is the fourth-largest o ...
led by J.B. Cleland, which also included Charles P. Mountford as
ethnologist Ethnology (from the grc-gre, ἔθνος, meaning 'nation') is an academic field that compares and analyzes the characteristics of different peoples and the relationships between them (compare cultural, social, or sociocultural anthropolog ...
and photographer, as well as botanist Thomas Harvey Johnston, and others. From 1940 to 1946 he was a Captain and Major in the Australian Army Medical Corps with service in Australia, Palestine,
Egypt Egypt ( ar, مصر , ), officially the Arab Republic of Egypt, is a List of transcontinental countries, transcontinental country spanning the North Africa, northeast corner of Africa and Western Asia, southwest corner of Asia via a land bridg ...
,
New Guinea New Guinea (; Hiri Motu: ''Niu Gini''; id, Papua, or , historically ) is the world's second-largest island with an area of . Located in Oceania in the southwestern Pacific Ocean, the island is separated from Australia by the wide Torres ...
, and
Borneo Borneo (; id, Kalimantan) is the third-largest island in the world and the largest in Asia. At the geographic centre of Maritime Southeast Asia, in relation to major Indonesian islands, it is located north of Java, west of Sulawesi, and e ...
, as medical officer in field ambulance and
Casualty Clearing Station In the British Army and other Commonwealth militaries, a Casualty Clearing Station (CCS) is a military medical facility behind the front lines that is used to treat wounded soldiers. A CCS would usually be located just beyond the range of enemy ...
,
pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in th ...
to general hospital, and malariologist. For his work in combating
malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. ...
in Papua New Guinea he was made a Member of the
Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established ...
in 1945.It's an Honour: MBE
/ref>Citation record of MB

/ref> Following his war-time service he was recruited by
Frank Macfarlane Burnet Sir Frank Macfarlane Burnet, (3 September 1899 – 31 August 1985), usually known as Macfarlane or Mac Burnet, was an Australian virologist known for his contributions to immunology. He won a Nobel Prize in 1960 for predicting acquired immune ...
to work at the
Walter and Eliza Hall Institute of Medical Research WEHI (), previously known as the Walter and Eliza Hall Institute of Medical Research, and as the Walter and Eliza Hall Institute, is Australia's oldest medical research institute. Sir Frank Macfarlane Burnet, who won the Nobel Prize in 1960 for ...
in Melbourne. Initially they worked on
smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...
in mice, for which he coined the term "
mousepox ''Ectromelia virus'' (ECTV) is a virus of the family ''Poxviridae'' and the genus ''Orthopoxvirus'' that causes mousepox, a disease of mice. It has only been seen in mouse colonies kept for research purposes but believed that wild populations o ...
", and later on the
genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar work ...
of poxvirus. In 1949, he received a fellowship to study at the Rockefeller Institute for Medical Research in New York City, he worked on
mycobacterium ''Mycobacterium'' is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae. This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis ('' M. tuberculosis'') ...
Bairnsdale bacillus, which causes
Buruli ulcer Buruli ulcer () is an infectious disease characterized by the development of painless open wounds. The disease is limited to certain areas of the world, most cases occurring in Sub-Saharan Africa and Australia. The first sign of infection is a ...
, the third most important mycobacterial disease worldwide after
tuberculosis Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, ...
and
leprosy Leprosy, also known as Hansen's disease (HD), is a long-term infection by the bacteria '' Mycobacterium leprae'' or '' Mycobacterium lepromatosis''. Infection can lead to damage of the nerves, respiratory tract, skin, and eyes. This nerve d ...
. Here he worked with and was influenced by René Dubos, who is one of the claimed originators of the phrase "
Think Globally, Act Locally The phrase "Think globally, act locally" or "Think global, act local" has been used in various contexts, including planning, environment, education, mathematics, business and the church. For many environmental activists, the phrase has been chan ...
".


In Canberra, 1949–2010

Returning to Australia in 1949, he was appointed Professor of
Microbiology Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, ...
at the new John Curtin School of Medical Research at the
Australian National University The Australian National University (ANU) is a public research university located in Canberra, the capital of Australia. Its main campus in Acton encompasses seven teaching and research colleges, in addition to several national academies an ...
,
Canberra Canberra ( ) is the capital city of Australia. Founded following the federation of the colonies of Australia as the seat of government for the new nation, it is Australia's largest inland city and the eighth-largest city overall. The ci ...
. Here he began studying viruses again, in particular the
myxoma virus ''Myxoma virus'' is a poxvirus in the genus ''Leporipoxvirus''. The two broad geographic types of ''myxoma virus'' are Californian and South American. Californian ''myxoma virus'' is found on the West Coast of the United States, the Baja Penins ...
. Throughout the 1940s and 1950s Australia had severe rabbit plagues. Fenner's work on the myxoma virus showed that initially it killed rabbits in 9 to 11 days and was 99.5% lethal. Under heavy selection pressure, the few rabbits that survived developed resistance, which meant that the pest was never completely eradicated, but their numbers were reduced. Prior to the release of the virus as a
biological control Biological control or biocontrol is a method of controlling pests, such as insects, mites, weeds, and plant diseases, using other organisms. It relies on predation, parasitism, herbivory, or other natural mechanisms, but typically also i ...
for the rabbits, Fenner,
Frank Macfarlane Burnet Sir Frank Macfarlane Burnet, (3 September 1899 – 31 August 1985), usually known as Macfarlane or Mac Burnet, was an Australian virologist known for his contributions to immunology. He won a Nobel Prize in 1960 for predicting acquired immune ...
, and Ian Clunies Ross famously injected themselves with myxoma virus, to prove it was not dangerous for humans. From 1967 to 1973 Fenner was Director of the John Curtin School of Medical Research. In 1977, he was named the chairman of the Global Commission for the Certification of Smallpox Eradication, the same year the last known case of naturally transmitted smallpox occurred in
Somalia Somalia, , Osmanya script: 𐒈𐒝𐒑𐒛𐒐𐒘𐒕𐒖; ar, الصومال, aṣ-Ṣūmāl officially the Federal Republic of SomaliaThe ''Federal Republic of Somalia'' is the country's name per Article 1 of thProvisional Constitut ...
. Fenner announced the
eradication of smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) cer ...
to the World Health Assembly on 8 May 1980. This success story is regarded as the greatest achievement of the
World Health Organization The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health. The WHO Constitution states its main objective as "the attainment by all peoples of the highest possible level o ...
. Before its eradication, smallpox was one of the world's most virulent viruses, responsible for millions of deaths, and leaving many of the victims who survived with disfiguring scars for life. Fenner had an abiding interest in the environment, and was the foundation Director of the Centre for Resources and Environmental Studies at the
ANU , image=Detail, upper part, Kudurru of Ritti-Marduk, from Sippar, Iraq, 1125-1104 BCE. British Museum.jpg , caption=Symbols of various deities, including Anu (bottom right corner) on a kudurru of Ritti-Marduk, from Sippar, Iraq, 1125–1104 BCE , ...
(1973), where he worked until his retirement in 1979, and which became part of the Fenner School of Environment and Society in 2007. He was a keen supporter of Australia having an ecologically, socially sustainable population. He was Emeritus Professor at the John Curtin School of Medical Research. In June 2010, he predicted in an interview with ''
The Australian ''The Australian'', with its Saturday edition, ''The Weekend Australian'', is a broadsheet newspaper published by News Corp Australia since 14 July 1964.Bruns, Axel. "3.1. The active audience: Transforming journalism from gatekeeping to gatew ...
'' the extinction of the human race within a century, primarily as the result of
human overpopulation Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, cultu ...
,
environmental degradation Environmental degradation is the deterioration of the environment through depletion of resources such as quality of air, water and soil; the destruction of ecosystems; habitat destruction; the extinction of wildlife; and pollution. It is defin ...
and
climate change In common usage, climate change describes global warming—the ongoing increase in global average temperature—and its effects on Earth's climate system. Climate change in a broader sense also includes previous long-term changes to ...
. He died in Canberra on the morning of 22 November 2010 after a brief illness, and days after the birth of his first great-grandchild.


Personal life

In 1944 Fenner met Bobbie Roberts. Ellen Margaret 'Bobbie' Roberts was a trained midwife and nurse. During World War II she worked on
malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. ...
with the Australian Army Nursing Service and through her work met Fenner. Shortly after they met they married in a Catholic ceremony (despite Fenner being an atheist). While keen to have children, the couple were infertile and with Bobbie having a hysterectomy in 1949 they decided to adopt. They subsequently adopted two children. Marilyn Aldus Fenner was born on 27 June 1950. Her biological parents were unknown. Victoria Fenner (born 1 March 1943) was adopted later at the request of her father (Fenner's younger brother Tom) after the death in a fire of Victoria's mother (Beverley Slaney). On 30 March 1958, Victoria Fenner shot and killed herself, with the assistance of another child,
Catherine Webb Catherine Webb (born 1986) is a British author. She also writes fantasy novels for adults under the name Kate Griffin, and she writes science fiction as Claire North. Life Webb was educated at the Godolphin and Latymer School, London, and th ...
. The coronial inquiry heard she had been passing through a period of extreme mental and spiritual disturbance and the coroner declared her death a suicide. Fenner himself was unable to fathom a motive, other than she was upset from reading
Neville Shute Nevil Shute Norway (17 January 189912 January 1960) was an English novelist and aeronautical engineer who spent his later years in Australia. He used his full name in his engineering career and Nevil Shute as his pen name, in order to protect h ...
's book, '' On the Beach''. Bobbie Fenner was diagnosed with cancer in 1989 and eventually died in 1994. Marilyn Fenner and her family then moved into the family home and looked after her father until his death.


Publications

* Frank Fenner and Francis Ratcliffe, ''Myxmatosis''. Cambridge University Press, 1965. *


Honours

Of the many honours Professor Fenner received throughout his career, there are the following: * Member of the
Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established ...
(MBE), 19 July 1945 * Companion of the
Order of St Michael and St George The Most Distinguished Order of Saint Michael and Saint George is a British order of chivalry founded on 28 April 1818 by George IV, Prince of Wales, while he was acting as prince regent for his father, King George III. It is named in honour ...
(CMG) 12 June 1976, in recognition of service to medical research * The Macfarlane Burnet Medal and Lecture of the
Australian Academy of Science The Australian Academy of Science was founded in 1954 by a group of distinguished Australians, including Australian Fellows of the Royal Society of London. The first president was Sir Mark Oliphant. The academy is modelled after the Royal Soc ...
, 1985 * The
Japan Prize is awarded to people from all parts of the world whose "original and outstanding achievements in science and technology are recognized as having advanced the frontiers of knowledge and served the cause of peace and prosperity for mankind." The P ...
(Preventive Medicine), 1988 (with Donald Henderson and Isao Arita) * Companion of the
Order of Australia The Order of Australia is an honour that recognises Australian citizens and other persons for outstanding achievement and service. It was established on 14 February 1975 by Elizabeth II, Queen of Australia, on the advice of the Australian Go ...
(AC) 26 January 1989, in recognition of service to medical science, to public health and to the environment *
Copley medal The Copley Medal is an award given by the Royal Society, for "outstanding achievements in research in any branch of science". It alternates between the physical sciences or mathematics and the biological sciences. Given every year, the medal is t ...
of the
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
, 1995 * Albert Einstein World Award of Science, 2000 * Clunies Ross Lifetime Contribution National Science and Technology Award, 2002 * Both the Frank Fenner building which houses the ANU Medical School and Faculty of Science, and a residential college Fenner Hall are named in honour of Frank Fenner. * WHO Medal *
Mueller Medal The Australian and New Zealand Association for the Advancement of Science (ANZAAS) is an organisation that was founded in 1888 as the Australasian Association for the Advancement of Science to promote science. It was modelled on the British As ...
(1964) and ANZAAS Medal (1980) * ANZAC Peace Prize *
Matthew Flinders Medal and Lecture The Matthew Flinders Medal and Lecture of the Australian Academy of Science is awarded biennially to recognise exceptional research by Australian scientists in the physical sciences. Nominations can only be made by Academy Fellows. Recipients Sourc ...
, 1967 * Britannica Australia Award for Medicine * 2002 Prime Minister's Prize for Science * ACT Senior Australian of the Year 2005 * The federal Division of Fraser, named for Jim Fraser, was renamed after Frank Fenner for the 2016 general election. This was due to the AEC's plans to name a seat in Victoria in honour of deceased Prime Minister
Malcolm Fraser John Malcolm Fraser (; 21 May 1930 – 20 March 2015) was an Australian politician who served as the 22nd prime minister of Australia from 1975 to 1983, holding office as the leader of the Liberal Party of Australia. Fraser was raised on hi ...
.


References


External links


Online Guide to Records at the South Australian Museum Archives


* ttps://web.archive.org/web/20110228170525/http://jcsmr.anu.edu.au/about/fenner/index.php EmerProfessor Frank Fenner's Webpage at JCMSR
Australian War Memorial Honours and Awards Database
* Originally published in ''Historical Records of Australian Science'', vol.24, no.1, pp. 109–133, 2013. {{DEFAULTSORT:Fenner, Frank 1914 births 2010 deaths Albert Einstein World Award of Science Laureates Australian virologists Australian microbiologists Smallpox eradication Fellows of the Australian Academy of Science Australian atheists Fellows of the Royal Society Foreign associates of the National Academy of Sciences Companions of the Order of Australia Australian Companions of the Order of St Michael and St George Australian Members of the Order of the British Empire Recipients of the Copley Medal People from Ballarat WEHI alumni