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The were a group of man-made
disease A disease is a particular abnormal condition that negatively affects the structure or function (biology), function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medica ...
s all caused by
environmental pollution Pollution is the introduction of contaminants into the natural environment that cause adverse change. Pollution can take the form of any substance (solid, liquid, or gas) or energy (such as radioactivity, heat, sound, or light). Pollutants, th ...
due to improper handling of
industrial waste Industrial waste is the waste produced by industrial activity which includes any material that is rendered useless during a manufacturing process such as that of factories, mills, and mining operations. Types of industrial waste include dirt and ...
s by
Japan Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north ...
ese
corporation A corporation is an organization—usually a group of people or a company—authorized by the state to act as a single entity (a legal entity recognized by private and public law "born out of statute"; a legal person in legal context) and ...
s. The first occurred in 1912, and the other three occurred in the 1950s and 1960s. Despite the moniker of 'four' becoming the prominent way to refer to the events,
Minamata disease Minamata disease is a neurological disease caused by severe mercury poisoning. Signs and symptoms include ataxia, numbness in the hands and feet, general muscle weakness, loss of peripheral vision, and damage to hearing and speech. In extreme ca ...
and Niigata Minamata disease were the same pollution disease spread by the same poison, just in different locations. Due to
lawsuit - A lawsuit is a proceeding by a party or parties against another in the civil court of law. The archaic term "suit in law" is found in only a small number of laws still in effect today. The term "lawsuit" is used in reference to a civil acti ...
s,
publicity In marketing, publicity is the public visibility or awareness for any product, service, person or organization (company, charity, etc.). It may also refer to the movement of information from its source to the general public, often (but not always ...
, and other actions against the corporations responsible for the pollution, as well as the creation of the Environmental Agency in 1971, increased public awareness, and changes in industrial practices, the incidence of these kinds of diseases declined after the 1970s. These cases also set precedents for private
tort law A tort is a civil wrong that causes a claimant to suffer loss or harm, resulting in legal liability for the person who commits the tortious act. Tort law can be contrasted with criminal law, which deals with criminal wrongs that are punishable ...
and civil law in issues of compensation for technology-related mass damage which continue to have repercussions in legal cases in Japan today.


Itai-itai disease

Itai-itai disease first occurred in 1912 within
Toyama Prefecture is a prefecture of Japan located in the Chūbu region of Honshu. Toyama Prefecture has a population of 1,044,588 (1 June 2019) and has a geographic area of 4,247.61 km2 (1,640.01 sq mi). Toyama Prefecture borders Ishikawa Prefecture to the we ...
. This disease was given the name "itai-itai" because this was the phrase affected people would frequently cry out; it translates into "it-hurts it-hurts disease".


Cause of itai-itai

The cause of itai-itai disease was determined to be
cadmium poisoning Cadmium is a naturally occurring toxic metal with common exposure in industrial workplaces, plant soils, and from smoking. Due to its low permissible exposure in humans, overexposure may occur even in situations where trace quantities of cadmium ...
in the
drinking water Drinking water is water that is used in drink or food preparation; potable water is water that is safe to be used as drinking water. The amount of drinking water required to maintain good health varies, and depends on physical activity level, ...
from the Jinzū River basin. The source of cadmium was discovered to be from
Mitsui Mining and Smelting Company is one of the largest ''keiretsu'' in Japan and one of the largest corporate groups in the world. The major companies of the group include Mitsui & Co. ( general trading company), Sumitomo Mitsui Banking Corporation, Nippon Paper Industri ...
. Mitsui Mining began to discharge cadmium into the Jinzū River in 1910. The cadmium poisoned the river, thus poisoning locals' source of water. Any person who drank that water or ate food that was grown with the contaminated water, such as rice, would be likely to show signs of itai-itai disease.


Symptoms of itai-itai

The first symptoms were spine and leg pain. However, as the disease progresses symptoms include: *debilitating
pain Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, ...
*
bone fractures A bone fracture (abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a partial or complete break in the continuity of any bone in the body. In more severe cases, the bone may be broken into several fragments, known as a '' ...
from mild traumas or activities (e.g., coughing or walking) *skeletal deformities *
anemia Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. When anemia comes on slowly, ...
* kidney disorders


Aftermath of itai-itai

Most people with itai-itai disease were confined to bed because walking caused severe pain. Residents of the surrounding area that were harmed by this disease filed a lawsuit against Mitsui Mining & Smelting Company in 1968. Residents won this lawsuit and began to conduct negotiations. Mitsui Mining formally admitted that itai-itai disease was caused by their discharge of cadmium into the Jinzū River. Mitsui Mining was also obliged to pay recovery costs for the land. This meant that they had to ensure the poisoned land was returned to a safe and cultivable state.


Minamata disease

The first report of
Minamata disease Minamata disease is a neurological disease caused by severe mercury poisoning. Signs and symptoms include ataxia, numbness in the hands and feet, general muscle weakness, loss of peripheral vision, and damage to hearing and speech. In extreme ca ...
originated in Minamata in
Kumamoto Prefecture is a prefecture of Japan located on the island of Kyūshū. Kumamoto Prefecture has a population of 1,748,134 () and has a geographic area of . Kumamoto Prefecture borders Fukuoka Prefecture to the north, Ōita Prefecture to the northeast, Miya ...
in the year 1956. Many of the earliest patients became insane from the symptoms and in some cases died within a month of being affected. After an extensive investigation, the Minamata disease was identified as a heavy metal poisoning, specifically methylmercury poisoning, transmitted by the ingestion of contaminated fish from
Minamata Bay Minamata is a small factory town. Minamata Bay is a bay on the west coast of Kyūshū island, located in Kumamoto Prefecture, Japan. The bay is part of the larger Shiranui Sea which is sandwiched between the coast of the Kyūshū mainland and t ...
. The
methylmercury Methylmercury (sometimes methyl mercury) is an organometallic cation with the formula . It is the simplest organomercury compound. Methylmercury is extremely toxic, and its derivatives are the major source of organic mercury for humans. It is ...
inside the contaminated fish attacked the affected patient's
central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all pa ...
, which caused a variety of symptoms.


Symptoms of Minamata disease

*numbing in the arms and legs *impairment of balance *fatigue * ringing in the ears *
tunnel vision Tunnel vision is the loss of peripheral vision with retention of central vision, resulting in a constricted circular tunnel-like field of vision. Causes Tunnel vision can be caused by: Eyeglass users Eyeglass users experience tunnel vision ...
* loss of hearing *decrease in communication skills (slurred speech) Most patients exhibited combinations of symptoms and did not show all symptoms.


Chisso Corporation

The cause of this contamination in Minamata bay was then traced back to Chisso Corporation's dumping of
methylmercury Methylmercury (sometimes methyl mercury) is an organometallic cation with the formula . It is the simplest organomercury compound. Methylmercury is extremely toxic, and its derivatives are the major source of organic mercury for humans. It is ...
into Minamata Bay. Chisso Corporation produced
acetaldehyde Acetaldehyde (IUPAC systematic name ethanal) is an organic chemical compound with the formula CH3 CHO, sometimes abbreviated by chemists as MeCHO (Me = methyl). It is a colorless liquid or gas, boiling near room temperature. It is one of the m ...
using
water Water (chemical formula ) is an inorganic, transparent, tasteless, odorless, and nearly colorless chemical substance, which is the main constituent of Earth's hydrosphere and the fluids of all known living organisms (in which it acts as a ...
,
acetylene Acetylene ( systematic name: ethyne) is the chemical compound with the formula and structure . It is a hydrocarbon and the simplest alkyne. This colorless gas is widely used as a fuel and a chemical building block. It is unstable in its pure ...
, mercury(II) sulfate as a catalyst and
manganese dioxide Manganese dioxide is the inorganic compound with the formula . This blackish or brown solid occurs naturally as the mineral pyrolusite, which is the main ore of manganese and a component of manganese nodules. The principal use for is for dry-cel ...
or since August 1951, ferric sulfide as a co-catalyst.
Acetaldehyde Acetaldehyde (IUPAC systematic name ethanal) is an organic chemical compound with the formula CH3 CHO, sometimes abbreviated by chemists as MeCHO (Me = methyl). It is a colorless liquid or gas, boiling near room temperature. It is one of the m ...
reacts with
acetic anhydride Acetic anhydride, or ethanoic anhydride, is the chemical compound with the formula (CH3CO)2O. Commonly abbreviated Ac2O, it is the simplest isolable anhydride of a carboxylic acid and is widely used as a reagent in organic synthesis. It is a ...
in order to produce
ethylidene diacetate Ethylidene diacetate is an organic compound with the formula (CH3CO2)2CHCH3. A colorless low-melting solid, it once served as a precursor to vinyl acetate. Preparation A major industrial route involves the reaction of acetaldehyde and acetic anh ...
, which is heated to produce
vinyl acetate Vinyl acetate is an organic compound with the formula CH3CO2CH=CH2. This colorless liquid is the precursor to polyvinyl acetate and ethene-vinyl acetate copolymers, important industrial polymers. Production The worldwide production capacity of ...
.
Acetaldehyde Acetaldehyde (IUPAC systematic name ethanal) is an organic chemical compound with the formula CH3 CHO, sometimes abbreviated by chemists as MeCHO (Me = methyl). It is a colorless liquid or gas, boiling near room temperature. It is one of the m ...
was also used to produce
acetic acid Acetic acid , systematically named ethanoic acid , is an acidic, colourless liquid and organic compound with the chemical formula (also written as , , or ). Vinegar is at least 4% acetic acid by volume, making acetic acid the main compon ...
by oxidizing acetaldehyde and
vinyl chloride Vinyl chloride is an organochloride with the formula H2C=CHCl. It is also called vinyl chloride monomer (VCM) or chloroethene. This colorless compound is an important industrial chemical chiefly used to produce the polymer polyvinyl chloride (PVC ...
, which is
polymerized In polymer chemistry, polymerization (American English), or polymerisation (British English), is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks. There are many f ...
to make PVC; however, the use of ferric sulfide had a downside: methylmercury (or organic mercury) was a by-product in the making of these chemicals due to its use. The methylmercury was then dumped into Minamata Bay as chemical waste. Chisso decided not to stop the use of the mentioned catalysts or the dumping of their byproducts into the bay until 1966. Today, Chisso makes compensation payments to all certified (recognized) patients of Minamata disease. Over 50 hectares of the bay were reclaimed, using the contaminated sludge from the bottom of the bay with a non-contaminated layer of soil on top.


Aftermath of Minamata disease

In 1970, the Japanese Water Pollution Control Act, which states that all factories are required by law to regulate disposal of dangerous chemicals, was enacted. In 1977, the Japanese government took on the task of cleaning Minamata Bay by vacuuming out 1.5 million cubic metres of methylmercury-contaminated sludge from the bottom of the bay and using them to reclaim over 50 hectares of the bay along with non-contaminated soil on top. Then in 1997, after fourteen years and $359 million, the Governor of Kumamoto Prefecture deemed Minamata Bay safe.


Niigata Minamata disease

In 1965, a number of patients in
Niigata Prefecture is a prefecture in the Chūbu region of Honshu of Japan. Niigata Prefecture has a population of 2,227,496 (1 July 2019) and is the fifth-largest prefecture of Japan by geographic area at . Niigata Prefecture borders Toyama Prefecture and Nag ...
exhibited signs of Minamata disease. Niigata Minamata was caused by
methylmercury Methylmercury (sometimes methyl mercury) is an organometallic cation with the formula . It is the simplest organomercury compound. Methylmercury is extremely toxic, and its derivatives are the major source of organic mercury for humans. It is ...
poisoning in the Agano River basin. However, this second outbreak of Minamata disease was discovered early on. The degree of this outbreak was minimal compared to that of the first Minamata disease that took place in
Kumamoto prefecture is a prefecture of Japan located on the island of Kyūshū. Kumamoto Prefecture has a population of 1,748,134 () and has a geographic area of . Kumamoto Prefecture borders Fukuoka Prefecture to the north, Ōita Prefecture to the northeast, Miya ...
. Investigation of the cause of the disease was given to the Niigata University medical department. There were a number of factors that could be the cause of this outbreak. Along the Agano River basin there were several plants that used mercury in production, agricultural chemicals were widely used in the area, and the last possible cause of the outbreak was said to be the cause of an earthquake that took place a year before the disease was discovered in Niigata.


Symptoms of Niigata Minamata disease

As the name implies, Niigata Minamata disease is similar to Minamata disease; they both share the similar symptoms: * numbness in the arms and legs * impairment of balance * fatigue * ringing in the ears * tunnel vision * loss of hearing * decrease in communication skills


Showa Denko

In the spring of 1966, the research team determined the most likely cause to the dumping of methylmercury from Showa Denko Corporation factory. Showa Denko was located upstream on the Agano River and, just like the Chisso corporation, produced methylmercury as a by-product and then dumped it into the Agano river. Much like Chisso corporation, Showa Denko declined all charges that they were at fault for the Niigata Minamata outbreak.


Aftermath of Niigata Minamata disease

After much controversy, Showa Denko was found guilty of negligence and was then forced to pay compensation payments to all those affected by Niigata Minamata disease. In the year that Niigata Minamata was discovered, 26 people were designated disease patients, and five died as a result of the methylmercury poisoning.


Yokkaichi asthma

Yokkaichi is a city located in Mie Prefecture, Japan. , the city had an estimated population of 310,259 in 142162 households and a population density of 1500 persons per km². The total area of the city is . Geography Yokkaichi is located in north-central ...
is a city in the center of Japan in
Mie Prefecture is a prefecture of Japan located in the Kansai region of Honshu. Mie Prefecture has a population of 1,781,948 () and has a geographic area of . Mie Prefecture is bordered by Gifu Prefecture to the north, Shiga Prefecture and Kyoto Prefecture t ...
; known as the "town of petroleum" as it produces almost a quarter of the total petroleum in Japan. Construction of the first
oil refinery An oil refinery or petroleum refinery is an industrial process plant where petroleum (crude oil) is transformed and refined into useful products such as gasoline (petrol), diesel fuel, asphalt base, fuel oils, heating oil, kerosene, li ...
in this area first began in 1955 and after construction many respiratory diseases emerged within the city and among neighboring districts.


Cause of Yokkaichi asthma

In the middle of this city was the largest heavy oil-fired
power station A power station, also referred to as a power plant and sometimes generating station or generating plant, is an industrial facility for the generation of electric power. Power stations are generally connected to an electrical grid. Many p ...
and refinery in Japan during this time period. Unfortunately, this refinery was not equipped with machines that could lower
sulfur dioxide Sulfur dioxide (IUPAC-recommended spelling) or sulphur dioxide (traditional Commonwealth English) is the chemical compound with the formula . It is a toxic gas responsible for the odor of burnt matches. It is released naturally by volcanic ac ...
emissions before releasing them into the air. In the early 1960s, respiratory diseases began to emerge in the general population of Yokkaichi and even in some neighboring districts. This increase in respiratory problems was then specified as Yokkaichi asthma. This form of
asthma Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, ...
was prevalent within Yokkaichi—5–10% of inhabitants aged 40 in Yokkaichi were reported to have chronic bronchitis, whereas less than 3% had the same disease in non-polluted areas.


Yokkaichi asthma relief system

To offer support for many of the people affected by disease, a public release system for air pollution was established in 1965. This set forth that all people in the Yokkaichi area who met the following criteria were paid by the program: #Specific diseases such as bronchial asthma, chronic bronchitis, pulmonary emphysema, and their complications. #In specific areas where the prevalence of that disease has increased. #Three years of residence within the specified area. Today, there are many laws regulating the amount of sulfur dioxide a factory can release into the air. These laws help keep the disaster of Yokkaichi Asthma from happening once again within Japan's borders.


See also

*
Environmental issues in Japan Environmental pollution in Japan has accompanied industrialization since the Meiji period. One of the earliest cases was the copper poisoning caused by drainage from the Ashio Copper Mine in Tochigi Prefecture, beginning as early as 1878. Repeat ...
*
Nitrogen oxide Nitrogen oxide may refer to a binary compound of oxygen and nitrogen, or a mixture of such compounds: Charge-neutral *Nitric oxide (NO), nitrogen(II) oxide, or nitrogen monoxide * Nitrogen dioxide (), nitrogen(IV) oxide * Nitrogen trioxide (), o ...
* Toroku arsenic disease * Yushō disease An-naka zinc refinery and cadmium pollution, Japan


References

{{Authority control Environmental disasters in Japan Health in Japan Pollution in Japan * Mass poisoning Water pollution in Japan Corporate scandals