Eastern Shuttle can refer to:
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Eastern Air Lines Shuttle, a former air shuttle service on the East Coast of the United States
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Eastern Shuttle (bus company)
Eastern Bus, also known as Eastern Shuttle and formerly Eastern Travel, was a provider of intercity bus service along the Interstate 95 corridor between New York City and Richmond, Virginia. It is one of several Chinatown bus lines and is now th ...
, a bus operator
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