ERDRP-0519
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ERDRP-0519 is an antiviral drug which is the first drug specifically developed to target the
measles Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...
morbillivirus. It acts as an inhibitor of the viral enzyme
RNA polymerase In molecular biology, RNA polymerase (abbreviated RNAP or RNApol), or more specifically DNA-directed/dependent RNA polymerase (DdRP), is an enzyme that synthesizes RNA from a DNA template. Using the enzyme helicase, RNAP locally opens th ...
which is essential for viral replication, and in animal studies showed good oral bioavailability and protected
ferret The ferret (''Mustela furo'') is a small, domesticated species belonging to the family Mustelidae. The ferret is most likely a domesticated form of the wild European polecat (''Mustela putorius''), evidenced by their interfertility. Other mus ...
s from otherwise lethal doses of a morbillivirus when administered up to three days after infection.


History

The research was done at Georgia State University and the Paul Ehrlich Institute.


See also

* Favipiravir * JK-05 * Sofosbuvir


References

Antiviral drugs Experimental drugs Trifluoromethyl compounds Pyrazoles Sulfonamides 4-Morpholinyl compunds Anilides Piperidines {{antiinfective-drug-stub