Transcription factor E2F3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''E2F3''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.
Interactions
E2F3 has been shown to
interact
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with
TFE3
Transcription factor E3 is a protein that in humans is encoded by the ''TFE3'' gene.
Function
TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is e ...
and
RYBP
RING1 and YY1-binding protein is a protein that in humans is encoded by the ''RYBP'' gene. Interactions
RYBP has been shown to interact with:
* Abl gene,
* CBX2,
* Caspase 10,
* E2F2,
* E2F3,
* Mdm2,
* RING1, and
* YY1
YY1 (Yin Yan ...
.
See also
*
E2F
References
Further reading
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External links
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Transcription factors
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