Eurycomanone is a

chemical compound A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element ...

that has been isolated from ''

Eurycoma longifolia ''Eurycoma longifolia'' (commonly called , Malaysian ginseng or long jack) is a flowering plant in the family Simaroubaceae. It is native to Indochina (Cambodia, Laos, Malaysia, Myanmar, Thailand and Vietnam) and Indonesia (the islands of Bor ...

'', also known as the longjack plant or tongkat ali. Eurycomanone is distributed throughout the plant, with the highest concentration in leaves. Researchers measured 6.0568 μg/mL in leaves, and only 0.3533 μg/mL in roots.

Mechanism of action

Eurycomanone is thought to be central to the sex-hormone increasing effects of ''

'' supplementation. In vitro, eurycomanone has been shown to enhance testosterone steroidogenesis through its inhibitory effects on aromatase, presumably causing testosterone production to increase to restore downstream estrogen homeostasis. As of November 2022, there are no studies investigating the effects of isolated Eurycomanone in human subjects. However, studies investigating the effects supplementation with ''

'' in human subjects have observed increases in free and total testosterone, with some studies showing increases or no changes in estradiol, luteinizing hormone, sex binding hormone globulin and follicle-stimulating hormone in both healthy and

hypogonadism Hypogonadism means diminished functional activity of the human gonad, gonads—the testicles or the ovary, ovaries—that may result in diminished biosynthesis, production of sex hormones. Low androgen (e.g., testosterone) levels are referred t ...

-affected men.

References

{{Reflist Quassinoids